The relationship between the hepatic lipase gene 250G/A polymorphism and the risk of hepatocellular carcinoma in Chinese population
Objective: To investigate the relationship between the hepatic lipase (HL) gene 250G/A polymorphism and the risk of hepatocellular carcinoma (HCC) in Chinese population. Methods: The PCR-RFLP was applied for detecting and calculating the distribution of HL gene 250G/A polymorphism of 286 HCC patients and 198 healthy people. Logistic regression analysis was used for investigating the relationship between the risk factors and risk of HCC. Results: A significant difference was found in comparisons of GA and AA genotype frequencies between two groups (both P<0.05). The risk of HCC was significantly higher in individuals with AA and GA genotype than in GG genotype. Logistic regression analysis showed that the GA+AA genotype of 250G/A polymorphism was a risk factor of HCC. Conclusion: Patients carrying the mutant gene A allele (rs2070895) may increase the risk of HCC.