论著 Original Article

中国人群肝脂酶基因250G/A多态性与肝细胞癌发生风险的关系

Published at: 2016年第36卷第9期

李美梁 1 , 李艳春 1 , 赵鸿皓 1 , 胡庆 1
1 湖南省人民医院病理科,长沙 410005
通讯作者 艳春 李 Email: 1425649618@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.09.029
基金:

摘要

目的:探讨中国人群中肝脂酶基因250G/A位点多态性与肝细胞癌(以下简称肝癌)发病风险的相关性。方法:采用PCR-RFLP技术检测、计算286例肝癌患者和198例健康者肝脂酶基因250G/A位点基因型频率分布情况,并利用logistic回归分析各危险因素与肝癌发生风险的关系。结果:GA和AA基因型频率均存在显著组间差异(均P<0.05),携带GA、AA基因型的个体罹患肝癌的风险显著高于GG基因型。Logistic回归分析结果表明肝脂酶基因250G/A位点GA+AA基因型为肝细胞癌发生的危险因素。结论:携带突变基因A等位基因可能会增加肝癌的发病风险。


The relationship between the hepatic lipase gene 250G/A polymorphism and the risk of hepatocellular carcinoma in Chinese population

Abstract

Objective: To investigate the relationship between the hepatic lipase (HL) gene 250G/A polymorphism and the risk of hepatocellular carcinoma (HCC) in Chinese population. Methods: The PCR-RFLP was applied for detecting and calculating the distribution of HL gene 250G/A polymorphism of 286 HCC patients and 198 healthy people. Logistic regression analysis was used for investigating the relationship between the risk factors and risk of HCC. Results: A significant difference was found in comparisons of GA and AA genotype frequencies between two groups (both P<0.05). The risk of HCC was significantly higher in individuals with AA and GA genotype than in GG genotype. Logistic regression analysis showed that the GA+AA genotype of 250G/A polymorphism was a risk factor of HCC. Conclusion: Patients carrying the mutant gene A allele (rs2070895) may increase the risk of HCC.


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引用

引用本文: 美梁 李, 艳春 李, 鸿皓 赵, 庆 胡. 中国人群肝脂酶基因250G/A多态性与肝细胞癌发生风险的关系[J]. 临床与病理杂志, 2016, 36(9): 1399-1405.
Cite this article as: LI Meiliang, LI Yanchun, ZHAO Honghao, HU Qing . The relationship between the hepatic lipase gene 250G/A polymorphism and the risk of hepatocellular carcinoma in Chinese population[J]. Journal of Clinical and Pathological Research, 2016, 36(9): 1399-1405.