论著 Original Article

根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果及存活质量、时间比较

Published at: 2016年第36卷第10期

奚诚 1,2 , 江勇 1
1 苏州大学附属第三人民医院肝胆外科,江苏 常州 213000
2 江苏大学附属武进医院肝胆外科,江苏 常州 213000
通讯作者 勇 江 Email: yjiang8888@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2016.10.012
基金:

摘要

目的:比较根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果、存活质量及存活时间。方法:选择我院2011年1月至2014年12月收治的60例Ⅲ期胰腺癌患者进行回顾性分析,根据患者手术方式分为根治性手术组(A组,n=34)及姑息手术组(B组,n=26),比较两组术后并发症发生率、存活质量及术后1年、2年、3年生存率。结果:两组术后ClavienⅢ级、ClavienⅣ级及胰瘘发生率无统计学差异(P>0.05);A组ClavienⅡ级发生率为41.2%,高于B组15.4%(P<0.05);A组各项生活质量评分均高于B组(P<0.05);术后1、2、3年生存率分别为44.2%、21.2%、16.1%,B组为15.4%、8.0%、0,无统计学差异(P>0.05)。结论:根治手术治疗TNMⅢ期胰腺癌患者可取得更佳效果,术后1、2、3年生存率均高于姑息手术组,生活质量更高,且术后并发症未明显增加,具有较大可行性。


Comparison of the effects, survival quality and time between radical operation and palliative operation in treating patients with TNM Ⅲ stage pancreatic cancer

Abstract

Objective: To compare the effects, survival quality and time between radical operation and palliative operation in treating patients with TNM Ⅲ stage pancreatic cancer. Methods: Sixty patients with Ⅲ stage pancreatic cancer who were treated in our hospital between January 2011 and December 2014 were divided into radical operation group (group A, n=34) and palliative operation group (group B, n=26). The incidence of postoperative complications, survival quality and postoperative 1-, 2- and 3-year survival rates were compared between two groups. Results: There were no significant differences in Clavien Ⅲ, Clavien Ⅳ and incidence of pancreatic fistula between two groups after operation (P>0.05); the incidence rate of Clavien Ⅱ in group A (41.2%) was significantly higher than group B (15.4%) (P<0.05). Quality of life scores in group A were higher than group B (P<0.05). The 1-, 2- and 3-year survival rates in group A were 44.2%, 21.2% and 16.1% respectively, while in group B were 15.4%, 8.0% and 0, respectively (P>0.05). Conclusion: The effect of radical operation in the treatment of patients with TNM Ⅲ stage pancreatic cancer is better, and the postoperative 1-, 2- and 3-year survival rates are higher than palliative operation. The quality of life is higher and it will not increase postoperative complications.


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引用

引用本文: 诚 奚, 勇 江. 根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果及存活质量、时间比较[J]. 临床与病理杂志, 2016, 36(10): 1526-1530.
Cite this article as: XI Cheng, JIANG Yong . Comparison of the effects, survival quality and time between radical operation and palliative operation in treating patients with TNM Ⅲ stage pancreatic cancer[J]. Journal of Clinical and Pathological Research, 2016, 36(10): 1526-1530.