临床病例讨论 Case Analysis

辛伐他汀致横纹肌溶解1例

Published at: 2016年第36卷第5期

罗举 1 , 张婷 1
1 长沙市中心医院老年科,长沙 410117
通讯作者 举 罗 Email: 53185902@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.05.033
基金:

摘要

患者女,76岁,因“全身肌肉疼痛,伴乏力1周”入院。因冠心病长期服用降脂药“辛伐他汀(舒将之)20 mg/晚”,约2月前改用“辛伐他汀(京新)40 mg/晚”。入院后完善相关检查,肌酸激酶明显升高,肾功能轻度受损。诊断上考虑为:辛伐他汀导致的横纹肌溶解症。该病例特点:1)长期服用辛伐他汀未见不良反应,更换厂家及增加剂量2月后出现不良反应;2)肌酸激酶水平的显著升高;3)如此高的肌酶水平却并没有出现严重的肾功能损害,预后良好。


A case report: a severe rhabdomyolysis associated with simvastatin

Abstract

A 76-year-old female was hospitalized because of “generalized muscle pain, with weakness for 1 week”. The patient had coronary heart disease and take simvastatin 20 mg per night. In recent 2 months, she changed the drug manufacturer and take 40 mg per night. The patient’s creatine kinase increased significantly with a slight renal impairment. The diagnosis is: rhabdomyolysis caused by simvastatin. The case has follow features: 1) before replaced the manufacturer and increased the dose, the adverse effects never appear; 2) a significantly increased creatine kinase level; 3) such a high level of creatine kinase did not cause serious renal failure.


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引用

引用本文: 举 罗, 婷 张. 辛伐他汀致横纹肌溶解1例[J]. 临床与病理杂志, 2016, 36(5): 707-709.
Cite this article as: LUO Ju, ZHANG Ting . A case report: a severe rhabdomyolysis associated with simvastatin[J]. Journal of Clinical and Pathological Research, 2016, 36(5): 707-709.