论著 Original Article

颈动脉狭窄程度及血浆髓过氧化物酶水平对缺血性脑卒中的影响

张晶 1 , 龙小燕 2
1 湖南省常德市澧县人民医院
2 中南大学湘雅医院
通讯作者 晶 张 Email: 253920051@qq.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.10.11714/j.issn.2095-6959.2014.03.005
基金:

摘要

目的:分析不同颈动脉狭窄程度、不同血浆髓过氧化物酶(myeoloperoxidase, MPO)水平对狭窄侧颈动脉供血区发生缺血性脑卒中的影响。方法:对颈部血管彩色超声(carotid artery ultrasound)证实的120例单侧颈动脉狭窄病变,行头颅计算机断层扫描(computer tomography, CT)以明确每个病例狭窄侧颈动脉供血区中有无梗死灶。将病例分为MPO水平升高组和正常组,分析两组中梗死灶发生率的差异。通过颈部血管彩色超声检查测量值计算狭窄程度,将狭窄程度分为≤50%,50%-70%及≥70%三个级别,分析狭窄程度与病变同侧梗死灶发生的相关性,同时分析相同狭窄程度时不同MPO水平与发生梗死灶的相关性。结果:MPO升高组57例,其中有梗死灶的为43例,占75.43%;MPO正常组病例共63例,其中有梗死灶的为33例,占52.38%;两组间梗死灶的发生率具有显著差异(P<0.05)。颈动脉狭窄程度≤50%有68例,50%-70%有36例,≥70%有16例,三个级别狭窄程度中梗死灶的发生率分别为63.23%,63.89%,62.50%,三组间无显著差异(P>0.05)。颈动脉狭窄程度≤50%的68病例中,MPO升高32例,正常36例,分别有26例(81.25%)和17例(47.22%)发生梗死灶,梗死灶的发生率具有显著差异(P <0.05)。结论:针对动脉粥样硬化颈动脉狭窄病例,MPO升高组在狭窄侧颈动脉供血区发生缺血性脑卒中的风险较MPO正常组更大,而颈动脉狭窄程度对发生缺血性脑卒中的影响无统计学意义。


The effect of carotid stenosisdegreeand blood MPO levels on cerebral ischemic stroke

Abstract

Objective: To investigate the effect of carotid stenosis degree and serum level of myeoloperoxidase(MPO)on the occurrence of cerebral ischemic stroke and to promote our understanding of the risk factors for cerebral ischemic stroke. Methods: 120 cases with carotid stenosis confirmed by carotid arteryultrasound were included in present study.Computer tomography scan was performed to identify if there was infarction in all patients.The cases were divided into high MPO group and normal MPO group according to the serum MPO levels and each group was subdivided into three subgroups on the basis of the carotid stenosis degree(≤50%,50%-70%,≥70%).We compared the incidences of cerebral infarction in the groups,and analyzed the correlation between cerebral infarction incidence and the serum MPO levels or the carotid stenosis degree.Results: The incidence rate of cerebral infarction in highs MPO group (43/57, 75.43%) was significantly higher than that in normal MPO group(33/63, 52.38%).However the differences of cerebral infarction occurrence rates among the groups with different degree of carotid stenosis(≤50%, 50%-70%,≥70%)were not observed,respectively63.23%, 63.89%, 62.50% in each group.In the cases with lower carotid stenosis degree(≤50%) patients with high MPO level suffered cerebral infarction more frequently compared with patients having normal MPO level(P<0.05).Conclusion: In the patients with carotid stenosis,the serum MPO level, but not carotid stenosis degree were correlate with the occurrence of cerebral ischemic stroke.


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引用本文: 晶 张, 小燕 龙. 颈动脉狭窄程度及血浆髓过氧化物酶水平对缺血性脑卒中的影响[J]. 临床与病理杂志, , (): .
Cite this article as: zhang jing, long xiaoyan . The effect of carotid stenosisdegreeand blood MPO levels on cerebral ischemic stroke[J]. Journal of Clinical and Pathological Research, , (): .