肿瘤干细胞(cancer stem cells，CSCs)是肿瘤发生、发展、侵袭、转移、复发及耐药的决定性因 素。基于微环境对干细胞的重要影响作用，本课题组在前期研究中成功的将鼠诱导的多能干细胞 (mouse induced pluripotent stem cells，miPS)在肿瘤微环境的作用下诱导成CSCs，并发现Dsg2基 因和Dpagt1基因的表达分别上调了4倍和6倍。有研究表明Dsg2和Dpagt1在多种肿瘤中过表达，在 细胞黏附、增殖及恶性转化中起着至关重要的作用，并且与肿瘤干细胞关系密切。本文主要就 Dpagt1和Dsg2在Wnt/β-catenin、EGFR等信号通路中对肿瘤干细胞的作用及其信号通路间的相互联 系进行综述。
The signaling pathways related to Dpagt1 and Dsg2 and cancer stem cells
Cancer stem cells (CSCs) are considered as a key factor of tumor occurrence, development, invasion and metastasis, recurrence and chemotherapy resistance recently. In view of the important influence of microenvironment on stem cells, in our previous study, we originally developed a cell lines with CSCs' characteristics after culturing mouse induced pluripotent stem (miPS) cells under the condition of carcinoma microenvironment. And the transcripts of Dsg2 and Dpagt1 were found respectively up-regulated 4-fold and 6-fold by using microarray assessment and qPT-PCR. Some studies have shown that the overexpression of Dsg2 and Dpagt1 in a variety of tumors, and played an important role in cell adhesion, proliferation and malignant transformation, and closed to related CSCs. Now we will make a review about the related signaling pathways of Dpagt1 and Dsg2, such as Wnt/β-catenin, EGFR and its relationship with cancer stem cells.