综述 Review

miR-155在动脉粥样硬化中的研究进展

Published at: 2015年第35卷第12期

王兴波 1 , 曹运长 1
1 南华大学药学与生物科学学院生化与分子生物学教研室,湖南 衡阳 421001
通讯作者 运长 曹 Email: caoychang@163.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.12.033
基金:
湖南省高等学校科学研究项目 09B090

摘要

大量基础和临床研究表明,动脉粥样硬化(atherosclerosis,AS)是一种慢性炎症性疾病,炎症反应 贯穿AS的各个阶段,但炎症在AS发生发展中的调节机制仍然尚未完全阐明。microRNA(miRNA)是 一类长度为21~25个核苷酸的小分子非编码RNA,在转录后水平通过降解或抑制靶标mRNA翻译来 调控靶基因的表达。已有研究证实,miRNA是参与心脑血管疾病的重要调控分子。MiR-155介导 的调节作用可广泛作用于内皮细胞、巨噬细胞、树突状细胞、血管平滑肌细胞、白细胞以及血小 板,通过对炎症相关基因的调控进而影响AS的发生发展。本文就miR-155对AS中所涉及到的不同 类型细胞的调节作用进行了综述。


Research progress in the roles of miR-155 in atherosclerosis

Abstract

A great number of basic and clinical studies show that atherosclerosis is a chronic inflammatory disease and that inflammatory responses exist in all stages of development of atherosclerosis. Despite a lot of progress was made in recent years, the detailed mechanisms modulating the inflammation in atherosclerosis have not been fully elucidated. MicroRNAs (miRNAs) are a category of small non-coding RNAs with the length of about 21 to 25 nucleotides that regulate gene expression post-transcriptionally through degradation and translational repression of target messenger RNAs (mRNAs). Substantial evidence demonstrates that miRNAs play vital roles in cardiocerebrovascular diseases. miR-155-mediated regulation is extensively involved in endothelial cells, macrophages, dendritic cells, vascular smooth muscle cells, leukocytes and platelets. miR-155 can modulate the expression of inflammation-related genes which affect the development of atherogenesis. This paper reviewed the regulatory roles of miR-155 in various cell types involved in atherosclerosis.


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引用

引用本文: 兴波 王, 运长 曹. miR-155在动脉粥样硬化中的研究进展[J]. 临床与病理杂志, 2015, 35(12): 2185-2190.
Cite this article as: WANG Xingbo, CAO Yunchang . Research progress in the roles of miR-155 in atherosclerosis[J]. Journal of Clinical and Pathological Research, 2015, 35(12): 2185-2190.