论著 Original Article

甲状腺功能减退与妊娠期糖尿病对孕妇妊娠结局及新生儿不良结局的影响

Published at: 2015年第35卷第12期

霍志平 1 , 李红霞 1 , 杜巍 1
1 中国石油天然气集团公司中心医院妇产科,河北 廊坊 065000
通讯作者 志平 霍 Email: huozhiping0235@126.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.12.020
基金:
廊坊市科技局资助项目 2014013112

摘要

目的:研究甲状腺功能减退与妊娠期糖尿病对孕妇妊娠结局及新生儿不良结局的影响。方法:选取2014年5月至2015年5月于我院进行产前检查并正常分娩的161例晚期孕妇作为研究对象,其中妊娠期糖尿病合并甲减组(Ⅰ组)42例、妊娠期糖尿病且甲状腺功能正常组(Ⅱ组)73例,妊娠期无糖尿病有甲减组(Ⅲ组)46例。对其进行OGTT试验及甲状腺功能检查,并对妊娠结局和新生儿结局进行检查分析。结果:对3组妊娠结局及新生儿不良结局进行比较,Ⅰ组妊娠期高血压疾病患病率是19.0%,远高于Ⅱ组的5.5%和Ⅲ组的9.3%;Ⅰ组的胎膜早破发生率是14.3%、产后出血发生率是4.8%、新生儿窒息的发生率是4.8%,都高于Ⅱ、Ⅲ组的发生率,且妊娠期高血压、胎膜早破、产后出血、新生儿窒息数据差异有统计学意义(P<0.05),而胎盘早剥、早产、新生儿低血糖发生率比较无统计学意义(P>0.05)。结论:甲状腺功能减退可增加GDM孕妇妊娠期高血压、胎膜早破、产后出血以及新生儿窒息的发生,在临床上改善妊娠期妇女的甲状腺功能问题有助于减少妊娠期妇女不良的妊娠结局。


Effects of hypothyroidism on pregnancy outcome and neonatal adverse outcomes in pregnant women with gestational diabetes mellitus

Abstract

Objective: To study the effects of hypothyroidism on pregnancy outcome and neonatal adverse outcomes in pregnant women with gestational diabetes mellitus. Methods: A total of 161 cases of late pregnant women who were treated in our hospital were selected from May 2014 to May 2015. The pregnancy with gestational diabetes mellitus (hypothyroidism group (group I, n=42), gestational diabetes and thyroid function in normal group (group II, n=73), gestational diabetes, 46 cases of hypothyroidism group (group III). OGTT test and thyroid function tests were conducted to examine the pregnancy outcome and the umbilical cord blood of newborns. Results: On three groups of pregnancy outcome and neonatal adverse outcomes were compared, group I gestational hypertension disease prevalence rate was 19.0%, far higher than that of group II 5.5% and group III 9.3%; group I prom incidence is 14.3%, postpartum hemorrhage incidence is 4.8%, neonatal asphyxia incidence rate was 4.8%, are higher than that of group II, III group the incidence and pregnancy induced hypertension, premature rupture of membranes, postpartum hemorrhage, neonatal asphyxia data difference had statistical significance (P<0.05), and placental abruption, premature birth, neonatal hypoglycemia occurred rate had no statistical significance (P>0.05). Conclusion: Hypothyroidism can increase the incidence of GDM in pregnant women with hypertension, premature rupture of membranes, postpartum hemorrhage and neonatal asphyxia, and improve the thyroid function of pregnant women in clinical practice to reduce the adverse pregnancy outcomes of pregnant women.


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引用

引用本文: 志平 霍, 红霞 李, 巍 杜. 甲状腺功能减退与妊娠期糖尿病对孕妇妊娠结局及新生儿不良结局的影响[J]. 临床与病理杂志, 2015, 35(12): 2112-2116.
Cite this article as: HUO Zhiping, LI Hongxia, DU Wei . Effects of hypothyroidism on pregnancy outcome and neonatal adverse outcomes in pregnant women with gestational diabetes mellitus[J]. Journal of Clinical and Pathological Research, 2015, 35(12): 2112-2116.