论著 Original Article

盐酸坦洛新缓释胶囊治疗输尿管结石的临床疗效分析

Published at: 2016年第36卷第5期

曾锋 1 , 曾令浩 1
1 湖北省麻城市人民医院泌尿外科,湖北 麻城 438300
通讯作者 锋 曾 Email: zach1125@163.com
DOI: 10.3978/j.issn.2095-6959.2016.05.024
基金:

摘要

目的:探析采用盐酸坦洛新缓释胶囊治疗输尿管结石的临床效果。方法:选取我院2013年3月至2015年3月收治的输尿管结石患者312例,均行体外冲击波碎石治疗,术后随机分为甲、乙、丙组各104例开展药物辅助排石治疗。甲组采取加味结石汤、双氯芬酸钠栓联合硝苯地平片,乙组在此基础上给予盐酸坦洛新缓释胶囊,丙组在此基础上应用盐酸坦索罗辛缓释胶囊。观察并比较三组患者的结石排净率、肾绞痛发生率及疼痛程度等情况。结果:乙组与丙组患者治疗后3 d、1周、2周与4周的结石排净率均显著高于甲组,同时,两组患者治疗后肾绞痛发生率与视觉模拟量表(visual analogue scale,VAS)疼痛评分均显著好于甲组,具有统计学意义(P<0.05)。而乙组患者治疗后3 d的结石排净率与治疗后肾绞痛发生率均显著好于丙组,具有统计学意义(P<0.05)。三组患者治疗后不良反应发生率比较差异均无统计学意义(P>0.05)。结论:输尿管结石患者术后采用盐酸坦洛新缓释胶囊与盐酸坦索罗辛缓释胶囊治疗均可获得良好的治愈效果,但盐酸坦洛新缓释胶囊的起效更为迅速,对肾绞痛的抑制效果更为显著,且具有较高临床安全性。


Analysis of the clinical effect of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones

Abstract

Objective: To analyzed the effect of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones. Methods: Selected 312 patients with ureteral calculi treated with extracorporeal shock wave lithotripsy in our hospital from March 2013 to March 2015, who were randomly divided into group A, group B and C group (n=104 cases). The patients in group A were taken modified stone soup, diclofenac and nifedipine; patients in group B were given tamsulosin hydrochloride sustained release tablets, patients in group C were used tamsulosin hydrochloride sustained release capsules. The rate of stone drainage, incidence of renal colic and degree of pain of three groups were observed and compared. Results: The rate of stone drainage of group B and group C were significantly higher than that in group A after treatment 3 d, 1 week, 2 weeks and 4 weeks, and the incidence of renal colic and degree of pain in two groups were significantly better in the first division, with statistical significance (P<0.05). The rate of stone drainage and incidence of renal colic in group C were significantly better than that in group B after treatment 3 d, with statistical significance (P<0.05). Conclusion: Tamsulosin hydrochloride sustained-release capsules and tamsulosin hydrochloride sustained release capsules can get good results for the treatment of ureteral calculi. But tamsulosin hydrochloride sustained-release capsules have more rapid effect, more significant inhibition in the occurrence of renal colic, and satisfactory clinical safety.


comments powered by Disqus

全文

引用

引用本文: 锋 曾, 令浩 曾. 盐酸坦洛新缓释胶囊治疗输尿管结石的临床疗效分析[J]. 临床与病理杂志, 2016, 36(5): 656-660.
Cite this article as: ZENG Feng, ZENG Linghao . Analysis of the clinical effect of tamsulosin hydrochloride sustained-release capsules in the treatment of ureteral stones[J]. Journal of Clinical and Pathological Research, 2016, 36(5): 656-660.