综述 Review

线粒体活性氧的产生及影响因素探讨

Published at: 2015年第35卷第9期

田留洋 1 , 刘昱圻 2 , 李泱 2
1 南开大学医学院,天津 300071
2 解放军总医院心内科,北京 100853
通讯作者 泱 李 Email: liyangbsh@163.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.09.021
基金:
国家自然科学基金项目 81470542/H0214

摘要

线粒体是重要的真核细胞的细胞器,通过氧化磷酸化为细胞提供90%以上能量。线粒体功能紊乱与氧化磷酸化功能损害和活性氧产生增多密切相关,是导致多种疾病的重要的病理基础。本文将针对线粒体产生活性氧的方式、影响因素以及活性氧对机体组织及细胞的影响进行阐述。


Reactive oxidative species caused by mitochondrion and relative factors

Abstract

Mitochondrionisan eukaryotic organelle that generatesmore than 90% of the energy in the cell by oxidative phosphorylation (OXPHOS). Mitochondrial dysfunction is an important pathophysiological mechanism for many common disorders, associated with impairing of OXPHOS and increasing reactive oxidative species (ROS) production. In this review we will discuss production of ROS caused by mitochondrion, affected factors and multiple effects on the tissue and cells.


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引用

引用本文: 留洋 田, 昱圻 刘, 泱 李. 线粒体活性氧的产生及影响因素探讨[J]. 临床与病理杂志, 2015, 35(9): 1686-1689.
Cite this article as: TIAN Liuyang, LIU Yuqi, LI Yang . Reactive oxidative species caused by mitochondrion and relative factors[J]. Journal of Clinical and Pathological Research, 2015, 35(9): 1686-1689.