第十届全国胃癌学术会议摘要集 Abstracts of the 10th Chinese Gastric Cancer Congress

Immunoglobin G as a novel prognostic biomarker for TNM stages I-III gastric cancer patients

Published at: 2015年第35卷第1期

Xiao-Jing Cheng 1 , ZhangLian-Hai 1 , WenXian-Zi 1
1 Gastrointestinal Carcinoma Translational Research Laboratory, Peking University Cancer Hospital & Institute, Beijing 100142, China
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.S122
基金:

摘要

Objective: Immunoglobin G (IgG) molecules are not only produced by differential B lymphocytes but also expressed in numerous epithelial cancer cells. They play important roles in promoting tumor cell growth and survival. However, their expression and function in gastric cancer remains unkown, this study was designed to investigate IgG expression and function in gastric cancer. Methods: IgG expression was evaluated by immunohistochemistry.The relationship between IgG expression and clinicopathological features and clinical outcomes were statistically analyzed. Results: Statistical analyses showed that IgG expression was more frequently detected in patients with cardiac cancer, intestinal type and no lymph node metastasis. Moreover, IgG expression was significantly related to the overall survivalin patients with tumor TNM stages I-III.Multivariate Cox regression analyses revealed that IgG expression was an independent prognostic factor in patients with tumor TNM stages I-III for OS. Conclusion: Our findings demonstrate that IgG was related to gastric cancer progression, and its expression can serve as a novel prognostic biomarker in gastric cancer patients.


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引用本文: Cheng Xiao-Jing , Lian-Hai Zhang, Xian-Zi Wen. Immunoglobin G as a novel prognostic biomarker for TNM stages I-III gastric cancer patients[J]. 临床与病理杂志, 2015, 35(1): S77.
Cite this article as: , , . [J]. Journal of Clinical and Pathological Research, 2015, 35(1): S77.