第十届全国胃癌学术会议摘要集 Abstracts of the 10th Chinese Gastric Cancer Congress

pNr stage is superior to the 7th edition UICC pN stage in gastric cancer after D2 resection according to different cut-points in cohorts with either at most 15 lymph nodes or more than 15 lymph nodes

Published at: 2015年第35卷第1期

LiBo-Fei 1 , ZhouZhi-Wei 1
1 Tumor Hospital Affiliated to Sun Yat-sen University, Guangzhou 510060, China
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.S010
基金:

摘要

Objective: We investigated the prognostic value of the lymph node ratio (LNR), determined different cutpoints in cohorts with examined lymph nodes (eLNs) ≤15 or eLNs >15, and compared hypothetical pNr with 7th edition UICC pN stage. Methods: A total of 1,772 gastric cancer patients undergoing D2 resection were enrolled. All patients were divided into two sub-cohorts according to eLNs ≤15 or eLNs >15. The optimal LNR cut-point was calculated using decision tree method. Homogeneity, discriminatory ability, and monotonicity of gradients of the pNr and UICC pNstages were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations. Results: The optimal cut-points were 0, 20, 35, 65 in eLNs >15 cohort and 0, 35, 70 in eLNs ≤15 cohort. pNr stage was an independent factor for gastric cancer prognosis. The pNr stage had higher linear trend and likelihood ratio χ2 scores and lower AIC values compared with those for UICC pN stage. Conclusion: The LNR cutpoint should be different according to the numbers of eLNs. pNr can predict survival more accurately than UICC pN stage in both the ≤15 and the >15 eLNs cohorts.


Abstract

Keywords:

comments powered by Disqus

全文

引用

引用本文: Bo-Fei Li, Zhi-Wei Zhou. pNr stage is superior to the 7th edition UICC pN stage in gastric cancer after D2 resection according to different cut-points in cohorts with either at most 15 lymph nodes or more than 15 lymph nodes[J]. 临床与病理杂志, 2015, 35(1): S31.
Cite this article as: , . [J]. Journal of Clinical and Pathological Research, 2015, 35(1): S31.