论著 Original Article

13例前列腺导管腺癌临床病理分析

Published at: 2015年第35卷第6期

付娟娟 1 , 宋新兰 1 , 胡小萍 1 , 孙振柱 1
1 新疆维吾尔自治区人民医院病理科,乌鲁木齐 830001
通讯作者 娟娟 付 Email: juanjuan805@163.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.048
基金:

摘要

目的:探讨前列腺导管腺癌的临床及病理组织学特征。方法:对13例前列腺导管腺癌进行光镜观察、免疫组织化学标记,鉴别诊断。结果:混合腺泡腺癌的导管腺癌最多见,占61.35%,大多发生于前列腺中央部,占76.92%,镜下呈乳头状、筛状或实性腺样排列,肿瘤细胞呈高柱状,胞浆丰富,嗜双色性,细胞异型性明显,大部分肿瘤细胞可见核仁。免疫组织化学标记PSA及AR均阳性13例,P504s阳性12例,P63及34βE12阳性1例,Ki-67增殖指数5%~80%。结论:前列腺导管腺癌与普通型腺癌相比,临床及病理特征均有差异,且需与高级别PIN、尿路上皮癌累及前列腺及尿道乳头状腺瘤相鉴别。


Clinicopathological analysis of 13 cases of prostate ductal adenocarcinom

Abstract

Objective: To explore the clinicopathological features, diagnosis and differential diagnosis of prostate ductal adenocarcinoma (DAP). Methods: A total of 18 cases of DAP were reported by microscopy, immunohistochemistry, differentia diagnosis. Results: Most cases were accompanied by conventional prostate adenocarcinoma (61.35%), most of the prostate ductal adenocarcinoma cases were central type (76.92%). Histologically, tumors consist mostly of papillary, cribriform and tubular structures. Tumor cells showed tall columnar shape and nuclear atypia, abundant cytoplasm, have double color and nucleolus. Immunohistochemically results showed the tumor cell was positive for PSA and AR, P504s positive 12 cases, P63 and 34βE12positive in 1 case. The proliferation index of Ki-67 was 5%~80%. Conclusion: There are both clinicopathological and immunohistochemcial differences between the ductal carcinoma and conventional prostate adenocarcinoma. Prostate ductal adenocarcinoma should be distinguished from high grade prostate intraepithelial neoplasm, urothelial carcinoma involving the prostate and papillary adenoma of urethra.


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引用

引用本文: 娟娟 付, 新兰 宋, 小萍 胡, 振柱 孙. 13例前列腺导管腺癌临床病理分析[J]. 临床与病理杂志, 2015, 35(6): 1117-1120.
Cite this article as: FU Juanjuan, SONG Xinlan, HU Xiaoping, SUN Zhenzhu . Clinicopathological analysis of 13 cases of prostate ductal adenocarcinom[J]. Journal of Clinical and Pathological Research, 2015, 35(6): 1117-1120.