论著 Original Article

顺尔宁联合布地奈德对支气管哮喘患儿炎症因子及气流受限的影响

Published at: 2015年第35卷第6期

严炜 1
1 湖北省武汉市第八医院儿科,武汉 430010
通讯作者 炜 严 Email: yanweiyw1@126.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.018
基金:

摘要

目的:研究顺尔宁联合布地奈德对支气管哮喘患儿炎症因子及气流受限的影响。方法:以我院2012年8月至2014年4月收治的100例支气管哮喘患儿为研究对象,随机数字表格法分为两组,对照组采取单纯布地奈德雾化吸入治疗,治疗组则在对照组基础上联合顺尔宁口服治疗,比较两组临床疗效、治疗前后肺功能、气流受限及主要炎症因子指标。结果:治疗组总有效率96.0%,较对照组的80.0%差异有统计学意义(P<0.05)。两组治疗后FVC[(3.35±0.45) vs. (2.78±0.37) L]、PEER [(6.76±0.51) vs. (5.21±0.45) L·s–1]、FEV1 [(2.83±0.32) vs. (2.21±0.36) L]比较差异有统计学意义(P<0.01)。另外,治疗组治疗后1周IL-6、TNF-α及hs-CRP、R5、R5-R20及R5-R10明显低于对照组(P<0.01)。结论:顺尔宁联合布地奈德治疗能有效改善患儿气道炎症反应,促进肺功能恢复,疗效明确,可作为小儿支气管哮喘治疗的重要手段。


Effects of montelukast tablets combined with budesonide on inflammatory factors and airflow limitation in children with bronchial asthma

Abstract

Objective: To study the effects of montelukast tablets combined with budesonide on inflammatory factors and airflow limitation in children with bronchial asthma. Methods: A total of 100 cases of children with bronchial asthma admitted into the hospital from August 2012 to April 2014 were chosen as the research object and were divided into two groups by the random number table method. The control group was treated with simple budesonide atomization inhalation while the treatment group with oral montelukast tablets on the basis of the control group. The clinical curative effect, the pulmonary function before and after the treatment, airway obstruction and the main indicators of inflammatory cytokines of the two groups were compared. Results: The total effective rate of the treatment group was 96%. Compared with 80% of the control group, the difference was statistically significant (P<0.05). The comparison of FVC [(3.35±0.45) vs. (2.78±0.37) L], PEER [(6.76±0.51) vs. (5.21±0.45) L·s–1] and FEV1 [(2.83±0.32) vs. (2.21±0.36) L] of the two groups after the treatment was statistically significant (P<0.01). In addition, IL-6, TNF-α, hs-CRP, R5, R5-R20 and R5-R10 of the treatment group a week before and after the treatment were significantly lower than those of the control group (P<0.01). Conclusion: Montelukast tablets combined with budesonide can obviously improve the patients’ airway inflammatory reactions, promote the recovery of pulmonary function and the curative effect is definite. The treatment can be used as an important means of treating bronchial asthma in children.


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引用

引用本文: 炜 严. 顺尔宁联合布地奈德对支气管哮喘患儿炎症因子及气流受限的影响[J]. 临床与病理杂志, 2015, 35(6): 960-964.
Cite this article as: YAN Wei . Effects of montelukast tablets combined with budesonide on inflammatory factors and airflow limitation in children with bronchial asthma[J]. Journal of Clinical and Pathological Research, 2015, 35(6): 960-964.