Experimental study of the curcumin in chronic cerebral ischemic rats
Objective: Explore the effect of curcunmin on chronic cerebral ischemia in rats, and its possible mechanism. Methods: Chronic cerebral ischemia (2-VO) model were prepared and given curcunmin or PBS after the surge. Eight weeks after the operation, Morris water maze were carried out to evaluate the learning and memory ability of the rats. The change of nerve cells were observed by Nissl staining; the expression of IL-1β, TNF-α were detected by western blot. Results: The learning and memory ability of the curcunmin group were significantly improved compared with the control group. The neurons pattern of curcumin treatment group was similar to the control group, while only scattered Nissl bodies were found the curcumin group; the expression of IL-1β, TNF-α in curcumin treatment group were significantly reduced (P<0.05). Conclusion: Curcumin can significantly improve the learning and memory ability of the chronic cerebral ischemic rat and its possible mechanism maybe involve in the anti-inflammation in neurons.