综述 Review

调节性B细胞在变应性疾病中对T细胞免疫的调节作用及其调节因素

Published at: 2015年第35卷第6期

王萌 1 , 曹志伟 1
1 中国医科大学附属盛京医院耳鼻咽喉科,沈阳 110004
通讯作者 志伟 曹 Email: caozw@sj-hospital.org
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.052
基金:
国家自然基金青年科学基金项目 81200730

摘要

由于B细胞(Breg cells)在免疫反应中具有介导特异性免疫反应、分泌抗体的作用,一直以来人们都认为B细胞在免疫反应中起到正性的免疫调节作用。然而,越来越多的研究证实B细胞同样具有负性的免疫调节作用。在变应性疾病中,某种具有调节功能的B细胞亚集可以通过分泌IL-10、TGF-I等细胞因子方式促进调节性T细胞(Treg cells)的分化或是直接抑制免疫性T细胞的增殖。这种B细胞的亚集被称作调节性B细胞,即B调细胞。同时,B调细胞所处的微环境对B调细胞的产生、增殖及分泌也起到调节作用。在这篇综述中,我们结合近年来的研究成果,讨论B调细胞在变应性疾病中,对T细胞免疫反应进行调节的可能机制以及B调细胞所处微环境中的某些因素对B调细胞的调节作用,并展望了B调细胞未来的研究方向。


Regulatory function on T cell immunity of regulatory B cell and its regulating factors in allergic diseases

Abstract

As B cells (Breg cells) can mediate specific immune responses and secrete antibodies in the immune response, it has long been believed that B cells play a positive regulatory role in the immune response. However, more and more studies have confirmed that B cells also have negative immunoregulatory effects. In allergic diseases, a B cell subset has regulatory function by means of secreting cytokines (IL-10, TGF-B, ect.) to promote differentiation of regulatory T cells (Treg cells) or directly inhibit the proliferation of T cells. This subset of B cells is called regulatory B cells. Meanwhile, the microenvironment also plays a regulatory role in differentiation and proliferation and secretion of Breg cells. In this review, we combine many research achievements in recent years, to discuss the possible regulatory mechanism of Breg cells on T cell immunity in allergic disease, and some regulatory factors in the microenvironment of Breg cells, and the research direction in the future of Breg cells.


comments powered by Disqus

全文

引用

引用本文: 萌 王, 志伟 曹. 调节性B细胞在变应性疾病中对T细胞免疫的调节作用及其调节因素[J]. 临床与病理杂志, 2015, 35(6): 1137-1143.
Cite this article as: WANG Meng, CAO Zhiwei . Regulatory function on T cell immunity of regulatory B cell and its regulating factors in allergic diseases[J]. Journal of Clinical and Pathological Research, 2015, 35(6): 1137-1143.