综述 Review

干扰素治疗慢性乙型肝炎疗效预测因素的研究进展

Published at: 2015年第35卷第6期

王坤 1 , 朱传龙 2
1 安徽医科大学附属安徽省立医院感染病科,合肥 230001
2 南京医科大学第一附属医院感染病科,南京 210029
通讯作者 传龙 朱 Email: chuanlong@yahoo.com
DOI: 10.3978/j.issn.2095-6959.10.3978/j.issn.2095-6959.2015.06.055
基金:
国家自然科学基金资助项目 81271713
安徽省第五批优秀青年科技基金滚动支持项目 1308085JGD09

摘要

对于慢性乙型肝炎患者,干扰素-α常作为首选抗乙肝病毒的药物之一,具有疗程有限、疗效持久的优点,但因其毒副作用多且抗病毒效率低等缺点限制了干扰素的临床应用。因此如何在抗病毒前预测干扰素-α抗病毒疗效至关重要。本文就影响干扰素-α疗效的各种因素进行简要综述,为临床医生选择干扰素-α治疗慢性乙型肝炎患者提供参考。


Research progress on predictors of interferon treatment in patients with chronic hepatitis B

Abstract

Interferon-alpha (IFN-α) remains as one of the first-line drugs used in chronic hepatitis B treatment. IFN-α has several advantages, such as finite course of therapy and long-term benefit. However, clinical application of IFN-α is still limited due to its side effect and inefficient antiviral ability. Therefore, it is very important for physicians to learn how to predict the efficacy of IFN-α treatment in patients with chronic hepatitis B. In this review, we focus on some various factors which can affect the efficacy of IFN-α treatment, hoping can provide reference for the clinicians.


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引用

引用本文: 坤 王, 传龙 朱. 干扰素治疗慢性乙型肝炎疗效预测因素的研究进展[J]. 临床与病理杂志, 2015, 35(6): 1157-1163.
Cite this article as: WANG Kun, ZHU Chuanlong . Research progress on predictors of interferon treatment in patients with chronic hepatitis B[J]. Journal of Clinical and Pathological Research, 2015, 35(6): 1157-1163.