MicroRNA and cardiovascular remodeling
MicroRNA is a short (18–25 nucleotides) and single-stranded non-coding RNA which is involved in almost all pathological and physiological process of diseases. Cardiovascular remodeling is the pathological basis of development of multiple cardiovascular diseases, in which microRNA plays an important role. In cardiac diseases, microRNAs affect myocardial cell hypertrophy, apoptosis, and interstitial fibrosis through a variety of mechanisms. In vascular remodeling diseases, microRNAs regulate proliferation and secretion of vascular smooth muscle cells through multiple signaling pathways.