目的：研究和探讨系统性红斑狼疮(systemic lupus erythematosus，SLE)患者尿白蛋白肌酐比值、肾小球滤过率(glomerular filtrationrate，GFR)水平情况及其与肾损害病变程度的关系，以期为临床诊治提供可靠依据。方法：入选2010年6月至2013年12月就诊于我院的SLE患者68例作为观察对象，将入选患者分为初治患者组37例和复治患者组31例，入院进行尿白蛋白肌酐比值、GFR检测，观察尿白蛋白肌酐比值、GFR在早期肾损害中的敏感性，同时通过其与病变程度的相关性研究进一步了解其临床意义和价值。结果：尿常规显示尿蛋白阳性患者为27例，阳性率为39.7%； 24 h尿白蛋白肌酐比值检测结果升高患者31例(45.6%)；而GFR检测降低为46例，检出率为67.6%，差异具有显著性(P<0.05)，检查两组患者尿白蛋白肌酐比值、GFR，发现初治患者组尿白蛋白肌酐比值显著低于复治患者组，初治患者组GFR水平显著高于复治患者组(P<0.05)。说明尿白蛋白肌酐比值、GFR检出率明显高于尿常规；其中复治患者组尿白蛋白阳性率、尿白蛋白肌酐比值升高率、GFR降低检测率明显高于初治患者组，说明尿白蛋白肌酐比值、GFR检测有助于提示早期肾损害，并且有利于提示肾损害的活动性和疾病程度。结论：针对SLE患者进行2尿白蛋白肌酐比值、GFR检测有助于早期发现肾损害，并且对患者疾病的活动度和严重性的临床判断有指导性意义，值得临床推广应用。
Analysis of the relationship between the patients with albumin creatinine ratio, the level of GFR and SLE with the severity of renal damage
Objective: To study and explore the systemic lupus erythematosus (SLE) patients with urinary albumin/creatinine ratio, glomerular filtrationrate (GFR) level and the severity of kidney damage, in order to provide a reliable basis for clinical diagnosis and treatment. Methods: Selected in 2010 June to 2013 year in December in our hospital for treatment of systemic lupus erythematosus patients 68 cases as the observation object, all the patients were divided into treatment group of 37 cases and retreatment of patients in group of 31 patients, admitted to the hospital for urine albumin creatinine ratio, GFR testing, observation of urinary albumin creatinine ratio value, the sensitivity of GFR in diagnosis of early renal at the same time, through the study of damage, its correlation with the severity of the further understanding of the clinical significance and value. Results: The results showed that patients with positive urine protein urine of 27 cases, the positive rate was 39.7%; the detection results of 24 h urinary albumin creatinine ratio increased in 31 cases (45.6%); and GFR detection is reduced to 46 cases, the detection rate was 67.6%, the difference was significant (P<0.05), two groups were examined with urine protein to creatinine ratio, GFR, that was significantly lower than that of patients with initial treatment group was significantly higher than that of urine albumin creatinine ratio, retreatment patients newly diagnosed GFR patients group (P<0.05). Description of urinary albumin to creatinine ratio, the detection rate of GFR was significantly higher than that of urine; the positive rate of patients with re treatment of urinary albumin, urinary albumin creatinine ratio increased, GFR decreased the detection rate was significantly higher than that of untreated patients, illustrate the urinary albumin creatinine ratio, the detection of GFR is helpful to the early renal damage, and is beneficial to renal damage the activity and the extent of the disease. Conclusion: For the patients with systemic lupus erythematosus (SLE) patients, 2 urinary albumin creatinine ratio and detection of GFR is helpful in the early diagnosis of renal damage and clinical judgment, activity and severity of disease has guiding significance, is worthy of clinical application.