文章摘要

miRNA靶向RAS-MAPK通路的表观遗传性激活与肿瘤

作者: 1丁苗, 2涂萍
1 江西中医药大学2014级中西医结合临床专业研究生，南昌 330004
2 南昌市第三医院内分泌代谢科，南昌 330009
通讯: 涂萍 Email: tuping8877@126.com
DOI: 10.3978/j.issn.2095-6959.2016.11.034
基金: 国家自然科学基金, 81260133 上海市糖尿病重点实验室开放课题资助项目, SHKLD-KF-1302

摘要

肿瘤作为一种难治性疾病，全世界都在为其治疗寻找新靶点。高度保守的RAS-MAPK通路在生物界大多数细胞内都广泛存在，主要通过各种级联反应刺激来控制细胞增殖分化等功能。体细胞基因突变编码RAS-MAPK通路经常发生在许多肿瘤中。miRNAs作为近年来研究较多的一种基因表达调控方式，其是通过与相关靶基因3’-UTR区结合来降解mRNA或抑制翻译表达。明确miRNA调控RAS-MAPK在肿瘤发生发展中的机制，可能为肿瘤的治疗提供新靶点。
关键词： RAS-MAPK信号通路 miRNAs 肿瘤

Epigenetic activation the miRNAs target the RAS-MAPK pathway and cancer

Authors: 1DING Miao, 2TU Ping
1 2014 Grade of Graduate, Integrated Traditional Chinese and Western Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004
2 Department of Endocrinology and Metabolism, the Nanchang Third Hospital, Nanchang 330009, China

CorrespondingAuthor: TU Ping Email: tuping8877@126.com

DOI: 10.3978/j.issn.2095-6959.2016.11.034

Abstract

As a refractory disease, people all over the world are looking for new targets for the treatment of tumor. The highly conserved RAS-MAPK pathway is involved in a wide range of cellular processes. It works with a variety of cascading reaction to control cell proliferation differentiation and other functions. Somatic genes mutations encoding the RAS-MAPK pathway often occur in many tumors. MicroRNAs are researched as a way of regulating the genic expression in recent years, and they degrade the mRNA or inhibit the translation by targeting the gene 3'-UTR region. Understanding the mechanism of how miRNA regulates the RAS-MAPK in the development of tumor may provide new targets for the treatment of tumor.

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