肾上腺素能受体与心肌肥大的研究进展
| 作者: |
1黄丹,
1毛建文,
1李春梅
1 广东药学院，广东省生物活性药物研究重点实验室，广州 510006 |
| 通讯: |
李春梅
Email: gylichunmei@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.07.038 |
| 基金: | 广东省自然科学基金, 2014A030310023 |
摘要
心肌肥大是一种较缓慢而有力的代偿形式，然而它不是无限度的，心肌肥大最终将引起心室功能异常而导致心力衰竭，这往往是心血管疾病患者的主要死因之一。肾上腺素能受体(adrenergicreceptor，AR)是介导儿茶酚胺作用的一类组织受体，研究表明AR与心肌肥大和心力衰竭的发生密切相关。因此，本文就几种AR与心肌肥大近年的研究进展进行综述，以便更好的了解心肌肥大的发生机理。
关键词：
肾上腺素能受体
心肌肥大
心力衰竭
Recent progress of adrenergic receptors on cardiac hypertrophy
CorrespondingAuthor: LI Chunmei Email: gylichunmei@126.com
DOI: 10.3978/j.issn.2095-6959.2015.07.038
Abstract
Cardiac hypertrophy is a relatively slow but powerful compensatory pattern. However, it is not unlimited, excessive cardiac hypertrophy will eventually cause ventricular dysfunction leading to heart failure, which is one of the main causes of death in patients with cardiovascular disease. Adrenergic receptor is a kind of receptors which mediate the effect of catecholamine. Studies have shown that there is a close relationship between adrenergic receptors and cardiac hypertrophy. Here, we reviewed the advance of study on relationship between adrenergic receptors and cardiac hypertrophy, in recent years. It will help us to better understand the mechanism of cardiac hypertrophy.