泛素羧基末端水解酶37
| 作者: |
1蔡枫,
1施毅
1 南京军区南京总医院呼吸内科，南京大学医学院，南京 210002 |
| 通讯: |
施毅
Email: shiyi56@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.01.027 |
| 基金: | 国家自然科学基金, 81470206 |
摘要
泛素羧基末端水解酶37(ubiquitin C-terminal hydrolase 37，UCH37或称UCH-L5)是泛素-蛋白酶体系 统中去泛素化酶家族的一员。UCH37与蛋白酶体的一个亚单位19S调节颗粒密切相关，可上调转 化生长因子β(transforming growth factor-β，TGF-β)通路并且可抑制细胞凋亡。UCH37在多种肿瘤 中有异常表达，在阿尔茨海默症、糖尿病肾病的发病机制中或许也起到一定作用。关于UCH37/ USP14抑制剂的研究为抗肿瘤药物提供了一个新靶点。
关键词：
泛素羧基末端水解酶37
去泛素化酶
泛素-蛋白酶体系统
肿瘤
Ubiquitin C-terminal hydrolase 37
CorrespondingAuthor: SHI Yi Email: shiyi56@126.com
DOI: 10.3978/j.issn.2095-6959.2015.01.027
Abstract
Ubiquitin C-terminal hydrolase 37 (UCH37, also called UCHL5) is a member of the deubiquitinating enzymes, which is crucial to the ubiquitin-proteasome system (UPS). UCH37 is closely related with 19S regulatory particles. In vitro, UCH37 could up-regulate transforming growth factor-β (TGF-β) signaling and inhibit cell apoptosis. UCH37 has been reported to be abnormally expressed in many human tumors and may be involved in the pathogenesis of Alzheimer's disease and diabetic nephropathy. Besides, the researches about the inhibitor of UCH37 and USP14 suggested a novel anticancer drug target.