文章摘要

雌激素对钙通道作用的研究进展

作者: 1,2于向沉, 1,3高青华, 1郝丽英
1 中国医科大学药学院药物毒理学教研室，沈阳 110001
2 复旦大学上海医学院药理研究中心，上海 200032
3 中国医科大学基础医学院生理教研室，沈阳 110001
通讯: 于向沉 Email: xcyu14@fudan.edu.cn
高青华 Email: 94213239@qq.com
郝丽英 Email: lyhao@mail.cmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2015.02.027
基金: 国家自然科学基金, 30670761，30671726，31071004

摘要

雌激素是一种类固醇激素，在体内具有广泛的生物学活性。细胞膜钙通道是介导外钙内流的主要 途径，参与了细胞内的很多过程，包括细胞兴奋、增殖、分化和凋亡。大量研究表明，雌激素可 通过基因组效应机制影响神经系统、心血管系统以及其他组织细胞钙通道的表达和功能，也可通 过非基因组效应机制快速激活或者抑制多种不同钙通道的活性，并且多呈现一种非单调的量效关 系，本文就雌激素对钙通道作用的研究进展作一综述。
关键词： 雌激素 钙通道 钙离子

Research Advance of the Effect of Estrogen on Calcium Channels

Authors: 1,2YU Xiangchen, 1,3GAO Qinghua, 1HAO Liying
1 Department of Pharmaceutical Toxicology, School of Pharmaceutical Sciences, China Medical University, Shenyang 110001
2 Pharmacology Research Center, Shanghai Medical College, Fudan University, Shanghai 200032
3 Department of Physiology, School of Basic Medical Sciences, China Medical University, Shenyang 110001, China

CorrespondingAuthor: YU Xiangchen Email: xcyu14@fudan.edu.cn

DOI: 10.3978/j.issn.2095-6959.2015.02.027

Abstract

Estrogen is a kind of steroid hormone with a wide range of biological activities. Membrane calcium channels are the major entrance of Ca2+ influx into cells, which play important roles in a variety of intracellular processes, including cell excitation, proliferation, differentiation and apoptosis. It have been demonstrated that estrogen has a significant influence on the expression and function of the calcium channels in the nervous system, the cardiovascular system and other tissues through genomic mechanism. Additionally, recent studies have also suggested that estrogen even can promote or inhibit the activity of different calcium channels through nongenomic mechanism by showing non-monotonic dose-response characteristics. This review summarizes the progresses in the effects of estrogen on calcium channels.

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