Objective: To evaluate the influence of vital signs and clinical symptoms of whole course nursing intervention mode on school-aged children with nebulization therapy and clinical efficacy. Methods: 112 school-aged asthma patients admitted to our hospital from August 2015 to February 2016 were distributed to whole course nursing intervention mode group (A group, n=56) and routine nursing intervention mode group (B group, n=56) randomly. In A group, our experiment using whole course nursing intervention after the school-aged asthma children treated with nebulization therapy, while in B group, it used routine nursing intervention after the treated with nebulization therapy. Compared the vital signs and clinical symptoms and the satisfaction after intervened by using the two methods, respectively. Results: Under the whole course nursing intervention mode condition, the change of clinical symptoms, vital signs (such as blood oxygen saturation, heart rate, breathing) and the scores of daytime and nighttime symptom were better than the routine nursing intervention mode condition, with significant differences (P<0.05). Meanwhile, the rate of satisfaction in whole course nursing intervention mode group patients was 98.3%, which was significant higher than the routine nursing intervention mode group patients with the rate of satisfaction in patients was 83.4% (P<0.05). Conclusion: Whole course nursing intervention mode on school-aged asthma children with nebulization therapy can change the clinical symptoms, vital signs, treatment compliance and satisfaction, which is deserve to popularize and apply in clinic treatment associated with the symptoms of asthma.