Treatment for metastatic colorectal cancer has transferred simple chemotherapy to targeted combination therapy. The traditional maintenance treatment, which keep medication for patients till progress has been made or till patients could not tolerate the treatment-related toxicity, has been challenged by some new therapy strategies. Maintenance treatment dose not only consolidate the efficacy of first-line treatment, but also reduce the cumulative toxicity of chemotherapy. It can effectively improve the patients’ quality of life, slow down disease progression, and eventually prolong overall survival. Maintenance treatment has become a research focus on metastatic colorectal cancer chemotherapy.