红景天抗氧化及对细胞因子作用的研究进展
| 作者: |
1贺佳林,
2胡瑞成,
2戴爱国
1 南华大学附属马王堆医院呼吸内科，长沙 410016 2 湖南省老年医院呼吸疾病研究室，长沙 410016 |
| 通讯: |
贺佳林
Email: hjlkkk007@126.com 胡瑞成 Email: huruicheng@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.02.024 |
摘要
大量研究表明红景天具较好的抗氧化、抗炎及抗衰老作用。红景天苷能清除•O2、•OH、脂氧自 由基等，抑制脂质过氧化，并且提高内源性自由基清除系统中关键酶SOD、GSH-Px和CAT等的活 性，表明红景天苷的抗氧化作用主要是通过调控自由基的清除和抗氧化酶的活性而实现的。红景 天苷还能抑制炎性细胞因子IL-1β、IL-6、IL-18以及TNF-α、TGF-β1的表达和显著增加IFN-γ的水 平，表明其抗炎作用主要是通过调节细胞因子的表达而实现的。本文就近年来有关红景天所具有 的抗氧化及细胞因子作用研究现状进行了综述。
关键词：
红景天
抗氧化
细胞因子
Research progress in the effects on antioxidantion and cytokines of rhodiola
CorrespondingAuthor: HE Jialin Email: hjlkkk007@126.com
DOI: 10.3978/j.issn.2095-6959.2015.02.024
Abstract
Increasing researches reported that rhodiola has the effects of anti-oxidation, anti-inflammation, and anti-aging. Salidroside could eliminate free radicals such as •O2, •OH and lipid oxygen free radical, inhibit lipid peroxidation reaction and improve the activity of key enzymes including SOD, GSH-Px and CAT, which promotes the clearance of endogenous free radicals. These data demonstrated that the mechanism underlying the anti-oxidantion of rhodiola involves the inhibition of lipid peroxidation and the elimination of free radicals. Furthermore, salidroside could inhibit IL-1β, IL-6, IL-18, TNF-α and TGF-β1 expression, and increase IFN-γ level, indicating that the regulation of cytokines expression mediates the anti-inflammatory effect of rhodiola. This paper summarized the anti-oxidantion and cytokines of Rhodiola based on previous researches.