PINK1与糖代谢相关的研究进展
| 作者: |
1张娟,
1莫朝晖
1 中南大学湘雅附三医院内分泌科，长沙 410013 |
| 通讯: |
莫朝晖
Email: easd04mzh@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.058 |
摘要
同源性磷酸酶张力蛋白诱导的激酶1[phosphatase and tensin homologue (PTEN)-induced putative kinase 1，PINK1]是与帕金森相关的一种蛋白激酶，同线粒体功能密切相关。有研究表明，PINK1可能与肥胖、2型糖尿病(type 2 diabetes mellitus，T2DM)有关，在调节胰岛β细胞功能中有一定作用，某些治疗T2DM药物也参与PINK1途径调节。本文就近年关于PINK1与糖代谢相关研究进行综述。
关键词：
糖代谢
胰岛素抵抗
胰岛β细胞
线粒体
The study progress on the correlation between PINK1 and glucose metabolism
CorrespondingAuthor: MO Zhaohui Email: easd04mzh@126.com
DOI: 10.3978/j.issn.2095-6959.2015.06.058
Abstract
PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a protein kinase associated with Parkinson’s and closely related with mitochondrial function. Studies have shown that PINK1 may be involved in obesity, type 2 diabetes. Recent studies demonstrate that PINK1 is necessary to maintain function of pancreatic beta cells. Some diabetic drugs are also involved in the regulation of PINK1. This article reviewed the study on the correlation between PINK1 and glucose metabolism in recent years.