文章摘要

干扰素治疗慢性乙型肝炎疗效预测因素的研究进展

作者: 1王坤, 2朱传龙
1 安徽医科大学附属安徽省立医院感染病科，合肥 230001
2 南京医科大学第一附属医院感染病科，南京 210029
通讯: 朱传龙 Email: chuanlong@yahoo.com
DOI: 10.3978/j.issn.2095-6959.2015.06.055
基金: 国家自然科学基金资助项目, 81271713 安徽省第五批优秀青年科技基金滚动支持项目, 1308085JGD09

摘要

对于慢性乙型肝炎患者，干扰素-α常作为首选抗乙肝病毒的药物之一，具有疗程有限、疗效持久的优点，但因其毒副作用多且抗病毒效率低等缺点限制了干扰素的临床应用。因此如何在抗病毒前预测干扰素-α抗病毒疗效至关重要。本文就影响干扰素-α疗效的各种因素进行简要综述，为临床医生选择干扰素-α治疗慢性乙型肝炎患者提供参考。
关键词： 干扰素 慢性乙型肝炎 疗效

Research progress on predictors of interferon treatment in patients with chronic hepatitis B

Authors: 1WANG Kun, 2ZHU Chuanlong
1 Department of Infectious Disease, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001
2 Department of Infectious Disease, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

CorrespondingAuthor: ZHU Chuanlong Email: chuanlong@yahoo.com

DOI: 10.3978/j.issn.2095-6959.2015.06.055

Abstract

Interferon-alpha (IFN-α) remains as one of the first-line drugs used in chronic hepatitis B treatment. IFN-α has several advantages, such as finite course of therapy and long-term benefit. However, clinical application of IFN-α is still limited due to its side effect and inefficient antiviral ability. Therefore, it is very important for physicians to learn how to predict the efficacy of IFN-α treatment in patients with chronic hepatitis B. In this review, we focus on some various factors which can affect the efficacy of IFN-α treatment, hoping can provide reference for the clinicians.

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