文章摘要

前列腺癌表观弥散系数与血清前列腺特异抗原、游离前列腺特异抗原/血清总前列腺特异抗原的相关性

作者: 1张德营, 1陈亚明
1 皖北煤电集团总医院影像科,安徽 宿州 234000
通讯: 张德营 Email: zdy420481986@163.com
DOI: 10.3978/j.issn.2095-6959.2020.12.017

摘要

目的:对前列腺癌表观弥散系数(apparent diffusion coefficient,ADC)与血清前列腺特异抗原(prostate specific antigen,PSA)、游离前列腺特异抗原(free prostate specific antigen,FPSA)/血清总前列腺特异抗原(total prostate specific antigen,TPSA)的相关性进行分析,为临床前列腺癌的诊断与治疗提供依据。方法:回顾性分析2017年1月至2019年12月在皖北煤电集团总医院确诊的43例前列腺癌患者,作为研究组。选择同期在皖北煤电集团总医院接受健康检查的63例非前列腺癌老年男性为对照组。测量所有入选对象的血清总PSA水平、游离血清前列腺癌的特异性标志物水平、磁共振参数ADC。选择Spearman相关分析对前列腺癌患者磁共振参数ADC与血清PSA和FPSA/TPSA的相关性进行分析。结果:高分化组、中分化组、低分化组与对照着相比血清总PSA水平比较均明显升高;低分化组、中分化组与对照着相比,游离血清PSA与FPSA/TPSA相比均明显升高,差异有统计学意义(P<0.01)。研究组患者的TPSA和FPSA水平明显高于对照组,ADC和FPSA/TPSA明显低于对照组,差异有统计学意义(P<0.05)。Gleason评与TPSA和FPSA呈中度正相关(r=0.419,r=0.436,P<0.01),与ADC和FPSA/TPSA呈负相关(r=0.899,r=0.416,P<0.01)。结论:前列腺癌患者磁共振参数ADC、血清PSA与FPSA/TPSA有明显相关性。
关键词: 前列腺癌;磁共振成像;Gleason评分;前列腺癌的特异性标志物;表观弥散系数

Correlation between apparent diffusion coefficient and prostate specific antigen, free prostate specific antigen/total prostate specific antigen in prostate cancer

Authors: 1ZHANG Deying, 1CHEN Yaming
1 Department of Imaging, General Hospital of Wanbei Coal and Power Group, Suzhou Anhui 234000, China

CorrespondingAuthor: ZHANG Deying Email: zdy420481986@163.com

Abstract

Objective: To analyze the correlation between apparent diffusion coefficient (ADC) and serum prostate specific antigen (PSA), free prostate specific antigen (FPSA)/total prostate specific antigen (TPSA) and to provide basis for diagnosis and treatment of prostate cancer. Methods: From January 2017 to December 2019, 43 patients with prostate cancer diagnosed in our hospital were analyzed retrospectively as the study group of this study. A total of 63 elderly men with non-prostate cancer who received health examination in our hospital were selected as the control group. The total serum PSA level, PSA level of free serum prostate cancer and ADC were measured. The correlation between ADC and PSA, FPSA/TPSA was analyzed by Spearman correlation analysis. Results: Compared with the control group, the serum total PSA level of high differentiation group, medium differentiation group and low differentiation group was significantly increased; compared with the control group, the free serum PSA level of low differentiation group and medium differentiation group was significantly higher than that of FPSA/TPSA (P<0.01). The level of TPSA and FPSA in the study group were significantly higher than that in the control group, and the level of ADC, FPSA/TPSA was significantly lower than that in the control group (P<0.05). Gleason assessment were positively correlated with TPSA and FPSA (r=0.419, r=0.436, P<0.01), negatively correlated with ADC and FPSA/TPSA (r=0.899, r=0.416, P<0.01). Conclusion: There was significant correlation between ADC, PSA, FPSA/TPSA and differentiation of prostate cancer.
Keywords: prostate cancer; magnetic resonance imaging; Gleason score; prostate cancer specific markers; apparent diffusion coefficient