文章摘要

特发性膜性肾病生物标志物的研究进展

作者: 1张露露, 1张若杰, 1郭璇, 1吴红赤
1 哈尔滨医科大学附属第一医院肾内科,哈尔滨 150001
通讯: 吴红赤 Email: 2674724077@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.10.042
基金: 黑龙江省教育厅科学技术研究项目(12541264)。

摘要

膜性肾病(membranous nephropathy,MN)是一种自身免疫性肾病,是肾病综合征最常见的病理类型之一。MN可分为特发性膜性肾病(idiopathic membranous nephropathy,IMN)和继发性膜性肾病 (secondary membranous nephropathy,SMN),其中IMN占主要部分。目前,IMN的诊断、监测和预后评估主要依赖于肾病理活检、尿蛋白定量及肾功能变化,由于它们各自存在一定的局限性,使得IMN的诊断和治疗仍面临很多困难。发现并应用特异性生物标志物对IMN进行无创诊断、疾病变化监测及预后评估具有重要的意义。近年来,国内外学者对IMN进行了不断的探索,在血清、尿液中发现了一些具有重要指导价值的生物标志物。
关键词: 特发性膜性肾病;生物标志物;诊断;治疗及预后;血清;尿液

Research progress on biomarkers of idiopathic membranous nephropathy

Authors: 1ZHANG Lulu, 1ZHANG Ruojie, 1GUO Xuan, 1WU Hongchi
1 Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: WU Hongchi Email: 2674724077@qq.com

Foundation: This work was supported by the Science and Technology Research Project of Heilongjiang Department of Education, China (12541264).

Abstract

Membranous nephropathy (MN), an autoimmune nephropathy, is one of the most common cause of nephrotic syndrome. MN can be divided into idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (SMN), and the IMN is dominant. Currently, the diagnosis, monitoring, and prognosis evaluation of IMN are primarily dependent on renal biopsy, urine protein quantification, and renal function surveillance. Because of their limitations, the diagnosis and treatment of IMN still have many difficulties. Discovery and application of specific biomarkers for noninvasive diagnosis, disease surveillance, and prognosis assessment of IMN are of great significance. In recent years, many scholars have done a lot of research on IMN, and found some biomarkers with important guiding value in serum and urine.
Keywords: idiopathic membranous nephropathy; biomarkers; diagnosis; treatment and prognosis; serum; urine