文章摘要

eCyPA与受体CD147信号通路在多系统疾病中的研究进展

作者: 1季胜强, 1戚基萍
1 哈尔滨医科大学附属第一医院病理科,哈尔滨 150001
通讯: 戚基萍 Email: qijiping2003@163.com
DOI: 10.3978/j.issn.2095-6959.2020.10.039

摘要

亲环素A(cyclophilin A,CyPA)是一种具有肽基-脯氨酰顺反异构酶活性的广泛表达于真核、原核生物体内结构和功能保守的蛋白质分子。最初研究认为CyPA作为细胞内蛋白分子发挥功能作用,最近越来越多的研究发现机体在缺氧、感染、氧化应激等病理状态下,细胞内的亲环素(intracellular cyclophilin A,iCyPA)能分泌到细胞外以自分泌或旁分泌途径参与由CD147受体介导的信号通路发挥独特的生物学作用。本文主要介绍细胞外亲环素(extracellular cyclophilin A,eCyPA)与主要受体CD147介导的生物学活性通路的研究进展,旨在为以eCyPA为靶点对相关的疾病提供治疗的新思路。
关键词: 亲环素A;CD147;信号通路

Advances of eCyPA and receptor CD147 signaling pathway in multisystem diseases

Authors: 1JI Shengqiang, 1QI Jiping
1 Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: QI Jiping Email: qijiping2003@163.com

Abstract

Cyclophilin A (CyPA) is a ubiquitous and highly conserved protein with peptidyl prolyl isomerase activity that widely expressed in eukaryotic and prokaryotic organisms. Initially, research suggested that CyPA functions as an intracellular protein molecule. Recently, more and more studies have found that intracellular cyclophilin A (iCyPA) can be secreted extracellularly in an autocrine or paracrine pathway to participate the signaling pathways mediated by the CD147 receptor to play a unique biological role when the body is under pathological conditions such as hypoxia, infection, and oxidative stress. This review mainly introduces the recent study of extracellular cyclophilin A (eCyPA) and the main receptor CD147-mediated biological activity pathway, and hopes to better provide eCyPA as a new point of diagnosis and treatment for related diseases.
Keywords: cyclophilin A; CD147; signaling pathway