文章摘要

EB病毒在体内传播机制的研究进展

作者: 1肖芷珣, 1张声
1 福建医科大学附属第一医院病理科,福州 350005
通讯: 张声 Email: zhgshg@126.com
DOI: 10.3978/j.issn.2095-6959.2020.10.038
基金: 福建省医学创新课题(2017-CX-28)。

摘要

爱泼斯坦-巴尔病毒(Epstein-Barr virus,EBV)是一种常见的疱疹病毒,与多种淋巴瘤和上皮恶性肿瘤的发生发展有关。已知EBV在体内感染主要存在原发感染、潜伏感染和裂解性感染等一系列生物循环。EBV通过细胞膜上CD21独立/非独立途径入侵宿主细胞,环化的病毒末端重复序列与核小体结合成游离基因,修饰导致特定DNA序列甲基化和去甲基化,调节病毒从潜伏感染到裂解的转换;通过病毒DNA滚环复制模型形成单独的EBV基因组,在外泌体介导下EBV感染细胞转移mRNA到靶细胞,产生体内传播。深入研究EBV入侵宿主细胞及其体内复制、表达、释放、感染周围细胞的机制可为阻止EBV体内传播,抑制感染提供新线索。
关键词: 爱泼斯坦-巴尔病毒;感染;体内传播

Advances on the mechanism of Epstein-Barr virus transmission in vivo

Authors: 1XIAO Zhixun, 1ZHANG Sheng
1 Department of Pathology, First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China

CorrespondingAuthor: ZHANG Sheng Email: zhgshg@126.com

Foundation: This work was supported by Fujian Medical Innovation Project, China (2017-CX-28).

Abstract

Epstein-Barr virus (EBV) is a common herpesvirus that is associated with a variety of lymphoid and epithelial malignancies. It is known that EBV infection in the body mainly includes a series of biological cycles such as primary infection, latent infection, and lytic infection. EBV invades the host cell through the CD21 independent/independent pathway on the cell membrane. The circularized virus terminal repeat sequence combines with the nucleosome to form a free gene. The modification results in the methylation and demethylation of specific DNA sequences, regulating the virus from latent infection to The conversion of lysis; a separate EBV genome is formed by the viral DNA rolling circle replication model, and EBV-infected cells transfer mRNA to target cells under the exosomes, resulting in in vivo transmission. In-depth study of the mechanism by which EBV invades host cells and their replication, expression, release, and infection of surrounding cells can provide new clues to prevent EBV from spreading in vivo and inhibit infection.
Keywords: Epstein-Barr virus; infection; transmission in vivo