文章摘要

盐敏感性高血压钠代谢相关基因的研究进展

作者: 1曹镌文, 1尹新华
1 哈尔滨医科大学附属第一医院心血管内科第八病房,哈尔滨 150001
通讯: 尹新华 Email: yinxinhua5063@163.com
DOI: 10.3978/j.issn.2095-6959.2020.10.037
基金: 国家自然科学基金(81570437)。

摘要

我国血压正常的成年人群中盐敏感性的检出率为15%~42%,而合并高血压的人群盐敏感性,即盐敏感性高血压(salt-sensitive hypertension,SSH)检出率为28%~74%。SSH人群基数大,但至今尚缺乏特异性及一致性的测定标准。盐敏感性相关基因的发现为SSH的测定提供了更加科学的依据。研究表明,盐敏感性与高血压的发病机制均与肾钠代谢紊乱密切相关。
关键词: 盐敏感性高血压;基因;表观遗传学

Advances in sodium metabolism-related genes in salt-sensitive hypertension

Authors: 1CAO Juanwen, 1YIN Xinhua
1 Eighth Ward of Cardiovascular Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: YIN Xinhua Email: yinxinhua5063@163.com

Foundation: This work was supported by the National Natural Science Foundation of China (81570437) China.

Abstract

In China, the detection rate of salt sensitivity in normotensive adult population is 15%–42%, while the detection rate of salt sensitivity in the population with hypertension is 28%–74%, that is salt-sensitive hypertension (SSH). There are a number of SSH patients, but there is still a lack of specific and consistent measurement standards. The discovery of salt-sensitive genes provides a more scientific basis for the determination of SSH. Studies have shown that both salt sensitivity and the pathogenesis of hypertension are closely related to the disorder of renal sodium metabolism.
Keywords: salt-sensitive hypertension; gene; epigenetics