文章摘要

支气管哮喘合并肺部感染患者血清IL-4和IL-10水平测定及临床意义

作者: 1郑蓉蓉, 1王一江, 1谢林燕
1 南京医科大学附属江苏盛泽医院呼吸科,江苏 苏州 215228
通讯: 王一江 Email: 13776161910@163.com
DOI: 10.3978/j.issn.2095-6959.2020.10.009

摘要

目的:探究支气管哮喘合并肺部感染患者血清白细胞介素4(IL-4)和白细胞介素10(IL-10)水平测定及临床意义。方法:采用ELISA法检测2018年6月至2019年6月南京医科大学附属江苏盛泽医院收治且临床诊断为支气管哮喘急性发作患者90例的血浆IL-4和IL-10水平,比较不同分组血浆IL-4和IL-10水平的差异。结果:本研究纳入的支气管哮喘患者90例(哮喘组),其中单纯支气管哮喘45例(A组),支气管哮喘合并肺部感染45例(B组),健康对照组45例。两组人群中性别和年龄分布差异无统计学意义(均P>0.05),但在吸烟人群的分布上差异有统计学意义(P=0.04);支气管哮喘组血浆IL-4水平为(40.23±9.57) pg/mL,显著高于健康对照组的(15.73±2.26) pg/mL(P<0.05);但血浆IL-10水平显著低于健康对照组(P<0.05);单纯支气管哮喘组血浆IL-4水平为(33.55±6.19) pg/mL,显著低于支气管哮喘合并肺部感染组的(46.89±7.49) pg/mL(P<0.05);但血浆IL-10水平显著高于支气管哮喘合并肺部感染组(P<0.05)。结论:血浆IL-4和IL-10水平与支气管哮喘以及合并肺部感染均存在关联。
关键词: 白细胞介素4;白细胞介素10;支气管哮喘;肺部感染

Determination of serum IL-4 and IL-10 levels in patients with bronchial asthma complicated with pulmonary infection and its clinical significance

Authors: 1ZHENG Rongrong, 1WANG Yijiang, 1XIE Linyan
1 Department of Respiratory, Jiangsu Shengze Hospital Affiliated to Nanjing Medical University, Suzhou Jiangsu 215228, China

CorrespondingAuthor: WANG Yijiang Email: 13776161910@163.com

Abstract

Objective: To determination of serum interleukin 4 (IL-4) and interleukin 10 (IL-10) levels in patients with bronchial asthma complicated with pulmonary infection and its clinical significance. Methods: The plasma IL-4 and IL-10 levels of 90 patients admitted to Jiangsu Shengze Hospital Affiliated to Nanjing Medical University from June 2018 to June 2019 who were clinically diagnosed as having an acute attack of bronchial asthma were detected by ELISA, and the differences in plasma IL-4 and IL-10 levels between different groups were compared. Results: A total of 90 cases of bronchial asthma were included, including 45 cases of simple bronchial asthma (group A), 45 cases of bronchial asthma with pulmonary infection (group B), and 45 cases of healthy people (control group). There was no statistical difference in the distribution of sex and age indexes between the asthma group and control group (P>0.05), but there was statistical difference in the distribution of smokers (P=0.04); the serum IL-4 level in bronchial asthma group was (40.23±9.57) pg/mL, significantly higher than that in healthy control group [(15.73±2.26) pg/mL, P<0.05]; but the serum IL-10 level was significantly lower than that in healthy control group (P<0.05). The serum level of IL-4 in group A was (33.55±6.19) pg/mL, which was significantly lower than that in group B [(46.89±7.49) pg/mL, P<0.05], but the serum level of IL-10 was significantly higher than that in group B (P<0.05). Conclusion: Serum levels of IL-4 and IL-10 are associated with bronchial asthma and pulmonary infection.
Keywords: interleukin 4; interleukin 10; bronchial asthma; pulmonary infection