长骨骨缺损的组织工程治疗现状
| 作者: |
1黄希,
1王文波
1 哈尔滨医科大学附属第一医院骨三科，哈尔滨 150001 |
| 通讯: |
王文波
Email: Wang_wenbo@aliyun.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.02.032 |
| 基金: | 黑龙江省自然科学基金 (H201454)；黑龙江省普通高等学校骨干教师创新能力资助计划 (1054G028)。 |
摘要
临床中长骨骨缺损一直是骨外科治疗的挑战，通常由开放骨折后骨缺损、骨肿瘤切除骨段、慢性骨髓炎去除死骨等因素导致。尤其是长骨大段骨缺损，除了大段的骨缺损外常伴有软组织状况不佳或感染倾向。目前国内外治疗手段多样，骨移植、骨搬移术等已成为主要临床技术。随着干细胞生物学、生长因子、新型生物材料和3D生物打印技术的发展，新的治疗手段逐渐增多。
关键词：
长骨骨缺损；骨缺损；组织工程；细胞因子；富血小板血浆
Current status of tissue engineering therapy on long bone defects
CorrespondingAuthor: WANG Wenbo Email: Wang_wenbo@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2021.02.032
Foundation: This work was supported by the Heilongjiang Provincial Natural Science Foundation (H201454) and Innovation Ability Funding Plan for Key Teachers in Ordinary Institutions of Higher Learning of Heilongjiang Province (1054G028), China.
Abstract
In clinical practice, bone defect of long-bone has always been a challenge in orthopedic surgery, which is usually caused by bone defect after open fracture, segment resection of tumor bone, removing necrotic bone in chronic osteomyelitis and other factors. Especially the massive bone defects of long-bone contain not only the massive bone defects, but also poor soft tissue or infection. At present, there are various domestic and overseas treatment methods including main clinical techniques like bone transplantation and bone transport. With the development of stem cell biology, cytokines, new biomaterials and 3D bio-printing technology, new treatments are gradually increasing.
Keywords：
bone defects of long-bone; bone defects; tissue engineering; cytokines; platelet rich plasma