文章摘要

中性粒细胞CD64表达的影响因素研究进展

作者: 1,2,3齐林, 4王亚丽, 1付建珠, 1张朝, 1成志勇
1 保定市第一医院血液内科，河北 保定 071000
2 承德医学院研究生院，河北 承德 067000
3 石家庄市第四医院内科，石家庄 050000
4 保定市第一医院营养科，河北 保定 071000
通讯: 成志勇 Email: dzczy@163.com
DOI: 10.3978/j.issn.2095-6959.2021.09.032
基金: 河北省适用跟踪计划项目(G2018091)。

摘要

CD64为免疫球蛋白超家族成员，在早期诊断脓毒症等感染性疾病中，中性粒细胞CD64指数检测发挥着越来越重要的作用，随着研究的深入我们也发现了多种因素可以干扰CD64表达。如药物、肿瘤、手术等均可对CD64造成影响，本文就CD64的各种影响因素进行综述，旨在阐述中性粒细胞CD64指数在临床应用中的必要作用及适用范围。
关键词： 中性粒细胞；CD64；影响因素

Research progress in influencing factors of neutrophil CD64 expression

Authors: 1,2,3QI Lin, 4WANG Yali, 1FU Jianzhu, 1ZHANG Zhao, 1CHENG Zhiyong
1 Department of Hematology, Baoding No.1 Hospital, Baoding Hebei 071000, China
2 Graduate School, Chengde Medical University, Chengde Hebei 067000, China
3 Department of Medicine, Fourth Hospital of Shijiazhuang; Shijiazhuang 050000, China
4 Department of Nutriology, Baoding No.1 Hospital, Baoding Hebei 071000, China

CorrespondingAuthor: CHENG Zhiyong Email: dzczy@163.com

DOI: 10.3978/j.issn.2095-6959.2021.09.032

Foundation: This work was supported by the Applicable Tracking Plan Project in Hebei Province, China (G2018091).

Abstract

CD64 is a member of the immunoglobulin superfamily. In the early diagnosis of infectious diseases such as sepsis, neutrophil CD64 index detection plays an increasingly important role. With further research, we have also found a variety of factors that can interfere with the expression of CD64. CD64 can be affected by drugs, tumors, surgery, etc. In this review, we reviewed the various factors affecting CD64, aiming at expound the necessary role and application scope of neutrophil CD64 index in clinical application.
Keywords： neutrophils; CD64; influencing factors

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