文章摘要

膜性肾病的免疫学及遗传学相关研究

作者: 1高红玉, 1刘晓刚
1 哈尔滨医科大学附属第一医院肾内科,哈尔滨 150001
通讯: 刘晓刚 Email: hrb-lxg@163.com
DOI: 10.3978/j.issn.2095-6959.2020.09.044

摘要

膜性肾病(membranous nephropathy,MN)是一种以自身抗体攻击其自身抗原并在肾小球上沉积形成的免疫复合物的病理特点而命名的疾病。为延缓MN患者进入肾脏替代治疗时期的时间,明确其发病机制是首要问题。近年来国内外学者发现免疫学及遗传学机制在MN的发生中占据重要位置。本文主要对免疫学及遗传学与MN的相关性作一综述,旨在为MN机制的研究提供新思路。
关键词: 特发性膜性肾病;M型磷脂酶A2受体1;人类白细胞抗原;血小板反应素1型结构域7A

Study on immunological and genetic mechanism of membranous nephropathy

Authors: 1GAO Hongyu, 1LIU Xiaogang
1 Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor: LIU Xiaogang Email: hrb-lxg@163.com

Abstract

Membranous nephropathy (MN) is a disease named after the pathological characteristics of autoantibodies attacking its own antigen and forming immune complexes deposited on the glomerulus. In order to delay the time of MN patients entering the period of renal replacement therapy, it is the most important problem to clarify the pathogenesis of renal replacement therapy. In recent years, scholars at home and abroad have found that its immunological and genetic mechanisms play an important role in the occurrence of MN. This paper mainly reviews the correlation between immunology, genetics and MN, in order to provide new ideas for the study of the mechanism of MN.
Keywords: idiopathic membranous nephropathy; M type phospholipase A2 receptor 1; human leucccyte antigen; thrombospondin type-1 domain-containing 7A