文章摘要

奥卡西平联用氯硝西泮对癫痫患者的治疗效果

作者: 1揣兰香, 1孙志, 1赵新春
1 天津联勤保障部队第983医院神经内科,天津 300142
通讯: 揣兰香 Email: 2388407098@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.09.019

摘要

目的:研究癫痫患者应用奥卡西平联用氯硝西泮的治疗效果和并发症情况。方法:选取天津联勤保障部队第983医院2017年3月到2019年3月收诊的89例癫痫患者,回顾性分析患者的临床资料。采用计算机直接插入排序法将患者分为对照组(n=44)和实验组(n=45),对照组接受氯硝西泮治疗,另外实验组在对照组的基础上联用奥卡西平,观察和比较两组患者的康复机制和并发症等情况。结果:实验组治疗期间并发症发生次数、癫痫发生次数均明显低于对照组,治疗前两组癫痫患者生活质量量表-31(Quality of Life in Epilepsy Inventory-31,QOLIE-31)评分、汉密尔顿焦虑量表(Hamilton Depression Scale,HAMD)、汉密尔顿抑郁量表(Hamilton Anxiety Scale,HAMA)评分差异均较小,差异不具有统计学意义(P>0.05);治疗后实验组QOLIE-31,HAMD,HAMA评分均优于对照组,差异均具有统计学意义(P<0.05)。结论:奥卡西平与氯硝西泮对癫痫病症均具有较好的治疗效果,采用两种药物联用的方式为患者进行治疗,有利于减少患者的并发症和发症次数,提升其生活质量,降低其心理不良情绪。
关键词: 癫痫;奥卡西平;氯硝西泮;疗效;并发症

Effects of oxcarbazepine combined with clonazepam on patients with epilepsy

Authors: 1CHUAI Lanxiang, 1SUN Zhi, 1ZHAO Xinchun
1 Department of Neurology, 983 Hospital, Tianjin Joint Logistics Support Force, Tianjin 300142, China

CorrespondingAuthor: CHUAI Lanxiang Email: 2388407098@qq.com

Abstract

Objective: To study the effect of oxcarbazepine combined with clonazepam on the recovery and complications in patients with epilepsy. Methods: Eighty-nine patients with epilepsy admitted to 983 Hospital of Tianjin Joint Logistics Support Force from March 2017 to March 2019 were selected and their clinical data were analyzed retrospectively. The patients were divided into control group (n=44) and experimental group (n=45) by computer direct insertion sequencing method. The control group was treated with clonazepam, and the experimental group was treated with oxcarbazepine on the basis of the control group. The rehabilitation mechanism and complications of the two groups were observed and compared. Results: The results showed that the frequency of complications and epilepsy in the treatment group was significantly lower than that in the control group, there was no significant difference in quality of life scale for epilepsy-31 (QOLIE-31), Hamilton Anxiety Scale (HAMD) and Hamilton Anxiety Scale (HAMA) between the two groups (P>0.05), the QOLIE-31, HAMD and HAMA scores of the experimental group were significantly higher than those of the control group (P<0.05). Conclusion: Oxcarbazepine and clonazepam are effective in the treatment of epilepsy, it is necessary to use both drugs to treat patients, this is beneficial to reduce the complications and complications of patients, improve their quality of life, reduce their bad mood.
Keywords: epilepsy; oxcarbazepine; clonazepam; effect; complications