Objective: To explore the application value of standardized nutrition treatment process in critically ill patients with craniocerebral injury. Methods: From January 2016 to March 2019, 96 patients with severe craniocerebral injury were selected and divided into a control group and an observation group according to the time of admission, 48 cases in each group. Patients in the control group were given routine nutritional treatment, while patients in the observation group were given standardized nutritional treatment process. After 2 weeks of nursing intervention, nutritional status, inflammatory status, rehabilitation and complications were compared between the 2 groups. Results: The levels of serum hemoglobin (Hb), albumin (ALB), prealbumin (PAB) in the observation group were higher than those in the control group, while the positive nitrogen balance time was shorter than that in the control group (P<0.05). The levels of serum C-reactive protein (CRP) and lymphocyte count in the observation group were lower than that in the control group (P<0.05). The incidence of complications in the observation group (6.25%) was lower than that in the control group (22.92%) (P<0.05). The Glasgow Coma Score (GCS) score of the observation group was higher than that of the control group, and the time of anal exhaust, average hospital stay and mortality were significantly less than those of the control group (P<0.05). Conclusion: Early standardized nutritional therapy for patients with critical craniocerebral injury can effectively improve the nutritional and inflammatory status of patients, promote prognosis, and reduce complications, which is worthy of wide clinical promotion.