文章摘要

生命早期肠道菌群建立的影响因素

作者: 1张 坤, 1樊 赛男, 1吕 安平, 2张 金萍
1 上海交通大学附属第六人民医院儿科,上海 201106
2 上海交通大学附属第六人民医院东院儿科,上海 201106
通讯: 张 金萍 Email: zhang-jin-ping@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.037
基金: 浦东新区卫生与计划生育委员会卫生计生科研项目(PW2017D-7);浦东新区科技发展基金(PKJ2017-Y09)。

摘要

生命早期(包括胎儿、婴幼儿期)是肠道菌群形成的关键时期。研究表明生命早期肠道菌群的建立与演变会影响儿童甚至是成年后的健康,与日后的神经系统、免疫系统、内分泌系统等疾病密切相关。而其肠道菌群的建立受到产前母亲因素、分娩方式、喂养方式、胎龄、抗生素、微生态制剂的使用及环境因素等各种内、外因素的影响。
关键词: 生命早期;肠道菌群;影响因素

Influence factors of the establishment of intestinal flora in early life

Authors: 1ZHANG Kun, 1FAN Sainan, 1LÜ Anping, 2ZHANG Jinping
1 Department of Pediatrics, Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai 201106, China
2 Department of Pediatrics, East Campus of Shanghai Sixth People’s Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai 201106, China

CorrespondingAuthor:ZHANG Jinping Email: zhang-jin-ping@163.com

Foundation: This work was supported by Health and Family Planning Commission of Pudong New District, shanghai (PW2017D-7) and Science and Technology Development Foundation of Pudong New District, Shanghai (PKJ2017-Y09), China.

Abstract

The early life (including the fetus, infants, and young children) is a critical period for the establishment of intestinal flora. More studies have shown that the establishment and evolution of intestinal flora in early life will affect children’s health even in adulthood and is closely related to the future nervous system, immune system, endocrine system and other diseases. The establishment of its intestinal flora is affected by various internal and external factors such as prenatal maternal factor, mode of delivery, feeding methods, gestational age, use of antibiotics, probiotics, and environmental factors.
Keywords: early life; intestinal flora; influence factors