文章摘要

血清HBV pgRNA的特征及临床价值

作者: 1张媛媛, 1王莉娟, 1徐云芳
1 淮安市第四人民医院肝病研究所,江苏 淮安 223002
通讯: 徐云芳 Email: fyx-1027@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.035
基金: 淮安市科技计划项目(HAS201614)。

摘要

目前针对慢性乙型肝炎病毒(hepatitis B virus,HBV)感染的主要治疗手段是抗病毒治疗,但很难达到完全治愈,效果都不尽如人意。前基因组RNA(pregenomic RNA,pgRNA)是慢性HBV感染的新兴血清学标志物,是病毒蛋白和病毒DNA合成的模板,也是HBV cccDNA的直接转录产物。但最近已有研究发现了血清pgRNA的其他新功能。
关键词: 慢性;乙型肝炎;血清学标志物;pgRNA

Characteristics and clinical value of serum HBV pgRNA

Authors: 1ZHANG Yuanyuan, 1WANG Lijuan, 1XU Yunfang
1 Institute of Liver Disease Research, Huai’an No. 4 People’s Hospital, Huai’an Jiangsu 223002, China

CorrespondingAuthor: XU Yunfang Email: fyx-1027@163.com

Foundation: This work was supported by Huai'an Science and Technology fund Project, China (HAS201614).

Abstract

At present, the main treatment for chronic hepatitis B virus (HBV) infection is antiviral therapy, but it is difficult to achieve complete cure, and the effect is not satisfactory. Pregenomic RNA (pgRNA) is an emerging serological marker for chronic HBV infection. While pgRNA is principally the template for viral proteins and viral DNAs, additional novel functions for the serum pgRNA have recently been described.
Keywords: chronic; hepatitis B; serological marker; pregenomic RNA