文章摘要

肥胖相关高血压的研究进展

作者: 1李 婧雯, 1张 晓卉, 1尹 新华
1 哈尔滨医科大学附属第一医院心内科,哈尔滨 150001
通讯: 尹 新华 Email: yinxinhua5063@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.033
基金: 国家重点研发计划(2017YFB1401804)。

摘要

近年来越来越多的研究证实肥胖与血压升高密切相关。鉴于世界范围内肥胖与肥胖相关疾病的患病率上升,明确两者之间发生发展的病理生理机制对于肥胖人群高血压的诊断、预防及治疗意义重大。然而不同地域肥胖的诊断标准不同,肥胖相关高血压的病理生理机制与交感神经系统激活、肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)激活、瘦素抵抗、食欲素过表达等神经体液因素复杂影响相关。肥胖相关高血压患者群体心血管系统损害不容忽视。互联网健康干预,外科手术治疗及合理降压药选择也为肥胖相关高血压防治提供了新思路。
关键词: 肥胖;高血压;靶器官损害

Progress in obesity-related hypertension

Authors: 1LI Jingwen, 1ZHANG Xiaohui, 1YIN Xinhua
1 Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor:YIN Xinhua Email: yinxinhua5063@163.com

Foundation: This work was supported by the National Key Research and Development Program, China (2017YFB1401804).

Abstract

In recent years, more and more studies have shown that obesity is closely related to the increase in blood pressure. In view of the increase in the prevalence of obesity and obesity-related diseases worldwaid, the pathophysiological mechanism of the development between the two is of great significance for the diagnosis, prevention and treatment of hypertension in the obese people. However, there are different diagnostic criteria for obesity in different regions. The pathophysiological mechanism of obesity related hypertension is related to the complex influence of neurohumoral factors such as sympathetic nervous system activation, renin-angiotensin-aldosterone system (RAAS) activation, leptin resistance, orexin overexpression, and so on. Cardiovascular system damage in obesity related hypertension patients should not be overlooked. Internet health intervention, surgical treatment and reasonable choice of antihypertensive drugs also provide new ideas for prevention and treatment of obesity related hypertension.
Keywords: obesity; hypertension; target organ damage