文章摘要

SIRT7生物学功能及其与肿瘤发生发展关系的研究进展

作者: 1胡 烨, 2陈 思齐, 1,3谢 妮
1 南华大学临床学院,湖南 衡阳 421001
2 广州医科大学临床学院,广州 510000
3 深圳市第二人民医院生物样本库,广东 深圳 518035
通讯: 谢 妮 Email: xn100@szu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2020.04.031
基金: 国家自然科学基金(81972003);广东省自然科学基金(2017A030313668)。

摘要

SIRT7是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)依赖蛋白去乙酰化酶,对组蛋白H3的第18位赖氨酸残基(H3K18ac)有特异性去乙酰化作用。作为Sirtuins蛋白家族的成员之一,SIRT7是许多细胞活动的关键介质。越来越多的证据表明SIRT7的基本细胞程序功能对于致癌演变以及肿瘤生物学有重要的影响,因此SIRT7有望成为表观遗传药物治疗新靶点。
关键词: SIRT7;去乙酰化酶;肿瘤

Progress in the biological function of SIRT7 and its development in tumorigenesis

Authors: 1HU Ye, 2CHEN Siqi, 1,3XIE Ni
1 Clinical College, University of South China, Hengyang Hunan 421001, China
2 Clinical College, Guangzhou Medical University, Guangzhou 510000, China
3 BioBank, Shenzhen Second People’s Hospital, Shenzhen Guangdong 518035, China

CorrespondingAuthor:XIE Ni Email: xn100@szu.edu.cn

Foundation: This work was supported by the Natural Science Foundation of National (81972003) and Natural Science Foundation of Guangdong (2017A030313668), China.

Abstract

SIRT7 is a member of the nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase sirtuin family and a highly specific deacetylation of H3K18Ac (acetylated 18-position lysine residue of histone H3). Enzymes are key mediators of many cellular activities. There is increasing evidence that the basic cellular procedural function of SIRT7 has an important impact on oncogenic transformation and tumor biology, so SIRT7 is expected to become a new target for epigenetic drug therapy. Here, we describe the biological role of SIRT7 and summarize the key role of SIRT7 in various types of tumors.
Keywords: SIRT7; deacetylase; tumor