文章摘要

PDPN/CLEC-2活化血小板与疾病相关性的研究进展

作者: 1徐 芳, 1包 宇实
1 哈尔滨医科大学附属第一医院肾内科,哈尔滨 150001
通讯: 包 宇实 Email: baogemstone@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.028
基金: 黑龙江省自然科学基金项目(H201337)。

摘要

血小板表面C型凝集素样受体2(C-type lectin-like receptor-2,CLEC-2)与其内源性配体平足蛋白(podoplanin,PDPN)相互作用后,诱导血小板活化,在促进血栓形成、协助肿瘤细胞转移、调节炎症反应、调节肺部发育、参与人早孕期母-胎界面的表达与调控等方面起重要作用。
关键词: 血小板;平足蛋白;C型凝集素样受体-2;血栓形成;高凝

Research progress in the relationship between PDPN/CLEC-2 activated platelets and diseases

Authors: 1XU Fang, 1BAO Yushi
1 Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

CorrespondingAuthor:BAO Yushi Email: baogemstone@163.com

Foundation: This work was supported by the Nature Scientific Foundation of Heilongjiang Province, China (H201337).

Abstract

Platelet surface C-type lectin-like receptor-2 (CLEC-2) induces platelet activation after interacting with its endogenous ligand podoplanin (PDPN), and plays an important role in promoting thrombosis, assisting tumor cell metastasis, regulating inflammatory response, regulating lung development, and participating in the expression and regulation of maternal-fetal interface during early pregnancy.
Keywords: platelet; podoplanin; C-type lectin-like receptor-2; thrombosis; hypercoagulability