文章摘要

肾小球足细胞骨架蛋白的研究进展

作者: 1金 英, 1张 炯, 1王 金泉
1 南京大学医学院附属金陵医院(东部战区总医院)肾脏科,国家肾脏疾病临床医学研究中心,全军肾脏病研究所,南京 210016
通讯: 王 金泉 Email: doc_wjq@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.027
基金: 国家自然科学基金(81470944);国家重点研发计划(2018YFC1312705)。

摘要

足细胞是肾小球滤过屏障的重要组成部分,结构独特复杂。足细胞的细胞骨架决定着其形态、结构及对环境刺激的应答能力。足细胞突起部分由初级及次级突触构成。初级突触中的细胞骨架主要有微管与中间丝,次级突触即足突骨架则由肌动蛋白微丝组成。足细胞骨架蛋白受损会导致蛋白尿及肾小球疾病。而与细胞骨架成分有关的肾小球疾病,均可能在此亚细胞结构上寻找到治疗靶点。
关键词: 足细胞细胞骨架;微管;中间丝;肌动蛋白;蛋白尿

Advance of the podocyte cytoskeleton

Authors: 1JIN Ying, 1ZHANG Jiong, 1WANG Jinquan
1 National Clinical Research Center of Kidney Diseases, Jinling Hospital , Nanjing University School of Medicine, Nanjing 210016, China

CorrespondingAuthor:WANG Jinquan Email: doc_wjq@163.com

Foundation: This work was supported by National Natural Science Foundation (81470944) and National Key R&D Program (2018YFC1312705), China. 

Abstract

The specific architecture of podocyte cytoskeleton plays a unique role in the glomerular filtration barrier, which regulate the shape, structure and the ability to response environmental stimuli. The processes of podocyte are consisted of primary and secondary parts. A primary processes of podocyte is supported by intermediate filaments and microtubules , while the secondary processes are mainly supported by actin filaments. Even a slight impairment of the cytoskeleton will lead to proteinuria and glomerular diseases. It is possible to find the therapic target from the cytoskeleton proteins in the related glomerular diseases.
Keywords: podocyte cytoskeleton; microtubule; intermediate filament; actin; proteinuria