文章摘要

上消化道出血患者红细胞分布宽度、谷胱甘肽过氧化物酶、过氧化脂质的变化及其临床意义

作者: 1李 海深, 1宗 慧丽
1 周口市中心医院急诊内科,河南 周口 466000
通讯: 李 海深 Email: zkszxyylhs2018@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.009

摘要

目的:探讨上消化道出血(upper gastrointestinal bleeding,UGIB)患者红细胞分布宽度(red blood cell distribution width,RDW)、血清谷胱甘肽过氧化物酶(serum glutathione peroxidase,Se-GSH-Px)及过氧化脂质(lipid peroxide,LPO)的变化与患者出血量的关系,在治疗前后变化的意义。方法:选取周口市中心医院确诊的110例UGIB患者(UGIB组)、60例健康对象(对照组),检测两组血红蛋白(hemoglobin,Hb),红细胞(red blood cells,RBC),血小板(platelets,HCT),RDW,Se-GSH-Px及LPO水平;并对比UGIB组不同出血量患者治疗前后上述指标变化。结果:UGIB组患者的RDW,LPO水平显著高于对照组(P<0.05),UGIB组患者的Hb,RBC,HCT及Se-GSH-Px水平显著低于对照组(P<0.05)。UGIB组轻度出血患者的RDW,LPO水平显著低于中重度出血患者(P<0.05),轻度出血患者的Hb,RBC,HCT,Se-GSH-Px水平显著高于中重度出血患者(P<0.05)。UGIB患者治疗后的RDW,LPO水平显著低于治疗前(P<0.05),UGIB患者治疗后Hb,RBC,HCT,Se-GSH-Px水平显著高于治疗前(P<0.05)。结论:UGIB患者RDW,Se-GSH-Px,LPO与其出血量大小有一定的关系,上述指标变化对指导治疗有一定的临床价值。
关键词: 上消化道出血;红细胞分布宽度;谷胱甘肽过氧化物酶;过氧化脂质

Changes of red blood cell distribution width, glutathione peroxidase and lipid peroxide in patients with upper gastrointestinal bleeding and their clinical significance

Authors: 1LI Haishen, 1ZONG Huili
1 Emergency Internal Medicine, Zhoukou Central Hospital, Zhoukou Henan 466000, China

CorrespondingAuthor:LI Haishen Email: zkszxyylhs2018@163.com

Abstract

Objective: To investigate the red blood cell distribution width (RDW), serum glutathione peroxidase (Se-GSH-Px) and lipid peroxide (LPO) in patients with upper gastrointestinal bleeding (UGIB) and the amount of bleeding in patients, the significance of changes before and after treatment. Methods: A total of 110 UGIB patients and 60 healthy subjects diagnosed in Zhoukou Central Hospital were selected as a UGIB group and a control group, respectively. Hemoglobin (Hb), red blood cells (RBC), platelets (HCT), RDW, Se-GSH-Px, and LPO levels were detected in the 2 groups. The above indicators in patients with different bleeding volume in the UGIB group were compared before and after treatment. Results: The levels of RDW and LPO in the UGIB group were significantly higher than those in the control group (P<0.05). The levels of Hb, RBC, HCT and Se-GSH-Px in the UGIB group were significantly lower than those in the control group (P<0.05). In the UGIB group, the RDW and LPO levels in patients with mild-bleeding were significantly lower than those in patients with moderate- to severe-bleeding (P<0.05); the levels of Hb, RBC, HCT and Se-GSH-Px in patients with mild-bleeding were significantly higher than those in patients with moderate to severe-bleeding (P<0.05). RDW and LPO levels of UGIB patients after the treatment were significantly lower than those before the treatment (P<0.05). Hb, RBC, HCT, Se-GSH-Px levels in the UGIB patients were significantly higher than those before the treatment (P<0.05). Conclusion: The RDW, Se-GSH-Px and LPO in UGIB patients have a certain relationship with the amount of bleeding, the changes of the above indicators has certain clinical value for guiding treatment.
Keywords: upper gastrointestinal bleeding; red blood cell distribution width; glutathione peroxidase; lipid peroxide