The clinical characteristics, pathological morphology and immunophenotype of 5 cases of cervical mixed adenocarcinoma-neuroendocrine carcinoma were analyzed. The onset age of 5 patients was 38–82 years old, with an average age of 54 years old, and they were admitted due to irregular vaginal bleeding or contact bleeding. Pathologic morphology showed small cell carcinoma with various adenocarcinoma components. Immunohistochemical staining showed that 5 of the 5 patients expressed broad-spectrum cytokeratin pan (CK-P), synaptophysin (Syn), nerve cell adhesion molecule 56 (CD56), and 2 expressed chromogranin (CgA), 2 cases expressed thyroid transcription factor 1 (TTF-l). CK-P, carcinoembryonic antigen (CEA) and neuroendocrine markers Syn, CgA and CD56 were all positive in 5 cases of adenocarcinoma. Five patients were followed up for 3 to 36 months after treatment, of which 3 died and 2 survived. Mixed adenocarcinoma of cervix-neuroendocrine carcinoma is a rare cervical malignant tumor with poor prognosis. Diagnosis needs to be combined with histological morphology and immunohistochemical markers.