文章摘要

肺淋巴管平滑肌瘤病1例并文献复习

作者: 1孟 玉秋, 2吴 蒙, 3李 红民, 1董 玉磊, 3刘 春玲
1 唐山市丰南区中医医院病理科,河北 唐山 063004
2 唐山市职业技术学院病理教研室,河北 唐山 063004
3 唐山市人民医院病理科,河北 唐山 063001
通讯: 刘 春玲 Email: lcl.1983.hi@163.com
DOI: 10.3978/j.issn.2095-6959.2020.02.039

摘要

对1例肺淋巴管平滑肌瘤病(pulmonary lymphangioleiomyomatosis,PLAM)的病理形态特点及免疫组织化学进行观察分析,并复习相关文献。在PLAM镜下可见肺组织较多囊腔样结构,内衬单层扁平上皮,囊壁、支气管及肺泡周围多灶性平滑肌样梭形细胞增生,正常至轻度异型,肺泡间隔、胸膜增厚。免疫组织化学示:平滑肌样梭形细胞中平滑肌肌动蛋白(smooth muscle actin,SMA)、人类黑色素瘤单克隆抗体(human melanoma black-45,HMB45)、孕激素受体(progestogen receptor,PR)均为阳性表达,雌激素受体(estrogen receptor,ER)弱阳性,囊壁衬附单层扁平上皮D2-40阳性。PLAM是一种持续进展的罕见肺部疾病,病理光学显微镜结合免疫组织化学表型可帮助确诊。
关键词: 肺淋巴管平滑肌瘤病;免疫组织化学;计算机断层扫描

Pulmonary lymphangioleiomyomatosis: A case report and review of literature

Authors: 1MENG Yuqiu, 2WU Meng, 3LI Hongmin, 1DONG Yulei, 3LIU Chunling
1 Department of Pathology, Traditional Chinese Medicine Hospital of Fengnan District, Tangshan Hebei 063004, China
2 Department of Basic Medicine, Pathological Teaching and Researching Section, Tangshan Vocational and Technical College, Tangshan Hebei 063004, China
3 Department of Pathology, Tangshan People’s Hospital, Tangshan Hebei 063001, China

CorrespondingAuthor:LIU Chunling Email: lcl.1983.hi@163.com

Abstract

The clinical and pathological features of a case of pulmonary lymphangioleiomyomatosis (PLAM) were analyzed and discussed in the literature. PLAM showed that the lung tissue has a lot of cystic structures and is lined with a single layer of flat epithelium. The smooth muscle-like spindle cells around the wall, bronchi and alveoli showed multifocal hyperplasia, with the thicken alveolar septum and pleural. Immunohistochemistry showed that smooth muscle actin (SMA), human melanoma black-45 (HMB45), progestogen receptor (PR), estrogen receptor (ER) and D2-40 had different degrees of positive expression. PLAM is a rare and progressive lung disease. Pathological features and immunohistochemistry are important diagnostic criteria.
Keywords: pulmonary lymphangioleiomyomatosis; immunohistochemistry; computed tomography