肺淋巴管平滑肌瘤病1例并文献复习
| 作者: |
1孟玉秋,
2吴蒙,
3李红民,
1董玉磊,
3刘春玲
1 唐山市丰南区中医医院病理科，河北 唐山 063004 2 唐山市职业技术学院病理教研室，河北 唐山 063004 3 唐山市人民医院病理科，河北 唐山 063001 |
| 通讯: |
刘春玲
Email: lcl.1983.hi@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.02.039 |
摘要
对1例肺淋巴管平滑肌瘤病(pulmonary lymphangioleiomyomatosis，PLAM)的病理形态特点及免疫组织化学进行观察分析，并复习相关文献。在PLAM镜下可见肺组织较多囊腔样结构，内衬单层扁平上皮，囊壁、支气管及肺泡周围多灶性平滑肌样梭形细胞增生，正常至轻度异型，肺泡间隔、胸膜增厚。免疫组织化学示：平滑肌样梭形细胞中平滑肌肌动蛋白(smooth muscle actin，SMA)、人类黑色素瘤单克隆抗体(human melanoma black-45，HMB45)、孕激素受体(progestogen receptor，PR)均为阳性表达，雌激素受体(estrogen receptor，ER)弱阳性，囊壁衬附单层扁平上皮D2-40阳性。PLAM是一种持续进展的罕见肺部疾病，病理光学显微镜结合免疫组织化学表型可帮助确诊。
关键词：
肺淋巴管平滑肌瘤病；免疫组织化学；计算机断层扫描
Pulmonary lymphangioleiomyomatosis: A case report and review of literature
CorrespondingAuthor: LIU Chunling Email: lcl.1983.hi@163.com
DOI: 10.3978/j.issn.2095-6959.2020.02.039
Abstract
The clinical and pathological features of a case of pulmonary lymphangioleiomyomatosis (PLAM) were analyzed and discussed in the literature. PLAM showed that the lung tissue has a lot of cystic structures and is lined with a single layer of flat epithelium. The smooth muscle-like spindle cells around the wall, bronchi and alveoli showed multifocal hyperplasia, with the thicken alveolar septum and pleural. Immunohistochemistry showed that smooth muscle actin (SMA), human melanoma black-45 (HMB45), progestogen receptor (PR), estrogen receptor (ER) and D2-40 had different degrees of positive expression. PLAM is a rare and progressive lung disease. Pathological features and immunohistochemistry are important diagnostic criteria.
Keywords：
pulmonary lymphangioleiomyomatosis; immunohistochemistry; computed tomography