文章摘要

流行性乙型脑炎发病机制的研究进展

作者: 1郭 莉琼, 1刘 晓晓, 1王 苗, 1张 燕菊, 1苏 丹丹, 1王 钦鹏, 1王 国娟, 1梁 成
1 兰州大学第二医院神经重症监护科,兰州 730030
通讯: 梁 成 Email: hongyan@126.com
DOI: 10.3978/j.issn.2095-6959.2020.02.035

摘要

流行性乙型脑炎是由乙脑病毒引起的急性人畜共患疾病。乙脑病毒感染人体后首先在外周组织中扩增,随后进入中枢神经系统导致广泛的中枢神经系统炎症及血脑屏障的破坏,这一过程可能涉及脑微血管内皮细胞间紧密连接的破坏、中枢神经系统炎症介质的浸润及神经元的死亡。乙脑的发病为家庭及社会带来沉重的负担。
关键词: 流行性乙型脑炎;血脑屏障;神经元损伤

Advances in research on pathogenesis of epidemic encephalitis B

Authors: 1GUO Liqiong, 1LIU Xiaoxiao, 1WANG Miao, 1ZHANG Yanju, 1SU Dandan, 1WANG Qinpeng, 1WANG Guojuan, 1LIANG Cheng
1 Department of Neurointensive Care, Second Hospital of Lanzhou University, Lanzhou 730030, China

CorrespondingAuthor:LIANG Cheng Email: hongyan@126.com

Abstract

Epidemic encephalitis B is an acute zoonotic, mosquito-borne infectious disease caused by encephalitis B virus infection. After infection, encephalitis B virus first replicates in peripheral tissues, and then entry into the central nervous system leads to extensive inflammation of the central nervous system and destruction of the blood-brain barrier, which may involve the destruction of tight connections between brain microvascular endothelial cells, infiltration of inflammatory mediators in the central nervous system and the death of neurons. The incidence of pidemic encephalitis B has brought heavy burden to the family and the society.
Keywords: epidemic encephalitis B; blood-brain barrier; neuronal damage