文章摘要

中性粒细胞与肿瘤的相关性

作者: 1商 安全, 1李 冬
1 同济大学附属同济医院检验科,上海 200065
通讯: 李 冬 Email: lidong@tongji.edu.cn
DOI: 10.3978/j.issn.2095-6959.2020.02.031
基金: 国家自然科学基金(81873975,81802084,81974314,81902984);上海市医疗卫生系统优秀学科带头人培养计划(2018BR31);上海市自然科学基金(19ZR1448800);上海市医学引导类科技支撑计划(19411964800);上海市同济医院临床培育项目[ITJ(ZD)1803,ITJ(ZD)1905,ITJ(QN)1905]。

摘要

癌症的进展不仅与肿瘤细胞本身有关,还与其他相关的参与者有关,包括癌细胞募集的免疫细胞、免疫细胞释放的促炎因子和细胞外基质。这些分子构成了肿瘤的微环境,在肿瘤的发生发展中起重要的作用。中性粒细胞是循环系统中数量最多的白细胞,是肿瘤微环境的重要组成部分。中性粒细胞在炎症和癌症之间起着重要的联系作用,在肿瘤的进展和转移中起积极的作用。中性粒细胞可能被认为是多种癌症类型的新靶点之一。
关键词: 中性粒细胞;中性粒细胞极化;中性粒细胞胞外陷阱;肿瘤

Relationship between neutrophils and tumors

Authors: 1SHANG Anquan, 1LI Dong
1 Department of Laboratory Medicine, Tongji Hospital of Tongji University, Shanghai 200065, China

CorrespondingAuthor:LI Dong Email: lidong@tongji.edu.cn

Foundation: This work was supported by the National Natural Science Foundation (81873975, 81802084,81974314,81902984),the Excellent Academic Leader Training Program of Shanghai Health System (2018BR31),the Medical Guidance Science and Technology Support Project of Shanghai (19411964800),the Natural Science Foundation of Shanghai (19ZR1448800),the Clinical Research and Cultivation Project of Shanghai Tongji Hospital [ITJ(ZD)1803,ITJ(QN)1905],China

Abstract

The progression of cancer is related not only to the tumor cells themselves, but also to other relevant participants, including immune cells recruited by cancer cells, pro-inflammatory factors released by immune cells and extracellular matrix. These molecules constitute the microenvironment of the tumor and play an important role in the occurrence and development of the tumor. Neutrophils are the largest number of leukocytes in the circulatory system and are an important part of the tumor microenvironment. Neutrophils play an important role in the relationship between inflammation and cancer, and play an active role in tumor progression and metastasis. Neutrophils may be considered as one of the new targets for many types of cancer. This paper reviews the latest progress of tumor inhibitory and pro-tumor activity of neutrophils in tumor microenvironment, as well as the development prospect of potential therapeutic strategies targeting neutrophils.
Keywords: neutrophils; polarizations of neutrophils; neutrophils extracellular traps; tumor