文章摘要

无抽搐电休克治疗对精神分裂症患者认知功能及其氧化自由基清除剂的影响

作者: 1张 炳奎, 1李 艳, 1杨 雪梅, 1郭 春光, 1孟 彬, 1赵 若莲, 1陈 颖, 1李 国琼, 1林 涛, 1郭 昕
1 昆明市精神病院科教科,昆明 650106
通讯: 张 炳奎 Email: 627781482@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.02.023
基金: 昆明市科技计划项目(昆科计字2013-04-04-A-S-01-3125号);昆明市五华区科技计划项目[五科信项(2013)31号]。

摘要

目的:探讨无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对精神分裂症患者认知功能及其氧化自由基清除剂的影响。方法:对符合国际疾病分类(10th International Classification of Diseases,ICD-10)诊断标准的精神分裂症患者进行前后对照研究,共收集50例。在MECT前后,对患者进行认知功能测评,检测基线血清超氧化物歧化酶(superoxide dismutase,SOD)、一氧化氮(NO)和谷胱甘肽过氧化物酶(GSH-Px)水平,探索MECT对患者认知功能影响及与氧自由基及其清除剂的相关性。结果:1)MECT治疗前后P300的N1潜伏期缩短,P3波幅降低,心理测试颜色连线测验、Stroop色词测验、威斯康星卡片分类测验(WCST-128)正确应答数及持续错误数差异有统计学意义(P<0.05);2)治疗前后SOD,GPX差异无统计学意义,NO水平较治疗前降低,差异有统计学意义(P<0.05);3)MECT治疗前NO水平与精神分裂症患者的认知功能有相关性。结论:1)MECT治疗对精神分裂症患者的认知功能是有改善的;2)MECT治疗后患者NO水平降低,且治疗前的NO水平与患者的认知功能有一定的相关性,提示其可能在认知功能中起一定的作用。
关键词: 精神分裂症;认知功能;氧化应激;无抽搐电休克治疗;一氧化氮

Effect of modified electroconvulsive therapy on the cognitive function and oxygen free radicals in schizophrenic patients

Authors: 1ZHANG Bingkui, 1LI Yan, 1YANG Xuemei, 1GUO Chunguang, 1MENG Bin, 1ZHAO Ruolian, 1CHEN Ying, 1LI Guoqiong, 1LIN Tao, 1GUO Xin
1 Department of Research & Education, Kunming Mental Hospitial, Kunming 650106, China

CorrespondingAuthor:ZHANG Bingkui Email: 627781482@qq.com

Foundation: This work was supported by the Project of Kunming Science and Technology Foundation Department (KKJZ2013-04-04-A-S-01-3125) and Science and Technology Plan Project of Wuhua District, Kunming [WKXX(2013)31]

Abstract

Objective: To study effect of modified electroconvulsive therapy on the cognitive function and oxygen free radicals in schizophrenic patients. Methods: A before and after treatment controlled study was carried out. A total of 50 schizophrenic meeting a diagnostic criteria of 10 th International Classification of Diseases (ICD-10) were recruited. To assess cognitive function and serum SOD, NO and GSH-Px. Results: Part of neuropsychological and electrophysiological testing results were improved after treatment. NO difference were found in serum SOD and GPX level before and after treatment (P<0.05). While serum NO level was lower after therapy. Before treatment there was relationship between serum NO level and cognitive function. Conclusion: The cognitive function of schizophrenic was improved by MECT. There was relationship between serum NO level and cognitive function before therapy, which suggests NO may play a role in cognitive function.
Keywords: schizophrenia; cognitive function; oxidative stress; modified electroconvulsive therapy; nitric oxide